The persistency of high levels of pSTAT3 expression in circulating CD4+ T cells from CIS patients favors the early conversion to clinically defined multiple sclerosis.

Massimiliano Mirabella, Giovanni Frisullo, Viviana Nociti, Raffaele Iorio, Agata Katia Patanella, Alessandro Marti, Pietro Attilio Tonali, Anna Paola Batocchi

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

18 Citazioni (Scopus)

Abstract

Not all patients with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) develop clinically defined MS (CDMS). At first clinical event we observed increased production of IL17, IFNgamma and IL10 by peripheral blood mononuclear cells from patients with CIS that remained high in remission. In CD4+ T cells pSTAT3 expression was higher in patients who subsequently converted to CDMS than in patients who did not and controls. The persistency of high levels of pSTAT3 in circulating CD4+ T cells from CIS patients after the first clinical event may favor the early conversion to CDMS.
Lingua originaleEnglish
pagine (da-a)126-134
Numero di pagine9
RivistaJournal of Neuroimmunology
Stato di pubblicazionePubblicato - 2008

Keywords

  • CIS
  • multiple sclerosis
  • pSTAT3

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