The PE multigene family: a 'molecular mantra' for mycobacteria

Giovanni Delogu, Mj Brennan

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

182 Citazioni (Scopus)

Abstract

The PE multigene family of Mycobacterium tuberculosis is remarkable in that it is composed of approximately 100 highly homologous genes that are found only in mycobacteria. Early evidence suggests that proteins encoded by certain members of this gene family could be present in the mycobacterial cell wall, impact antigen-presentation pathways and the ensuing host immune responses, and also provide a mechanism for generating antigenic diversity in mycobacteria.
Lingua originaleEnglish
pagine (da-a)246-249
Numero di pagine4
RivistaTrends in Microbiology
Volume10
Stato di pubblicazionePubblicato - 2002

Keywords

  • Amino Acid Sequence
  • Animals
  • Antigen Presentation
  • Antigens, Bacterial
  • Bacterial Proteins
  • Humans
  • Membrane Proteins
  • Mice
  • Models, Genetic
  • Molecular Sequence Data
  • Multigene Family
  • Mycobacterium tuberculosis
  • Sequence Analysis, Protein

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