The P2Y12 receptor: no active metabolite, no party

Carlo Patrono

doi:10.1038/nrcardio.2009.29

The P2Y12 receptor: no active metabolite, no party

Carlo Patrono

Risultato della ricerca: Contributo in rivista › Articolo in rivista

18 Citazioni (Scopus)

Abstract

Poor responders to clopidogrel have low levels of circulating active metabolite. However, in vitro experiments have shown that blood platelets from poor responders are fully inhibited by the active metabolite of this prodrug. Impaired platelet inhibition reflects inadequate plasma levels of active metabolites, and not differences in platelet P2Y12 receptor function.

Lingua originale	English
pagine (da-a)	271-272
Numero di pagine	2
Rivista	NATURE REVIEWS. CARDIOLOGY
Volume	6
DOI	https://doi.org/10.1038/nrcardio.2009.29
Stato di pubblicazione	Pubblicato - 2009
Pubblicato esternamente	Sì

Keywords

Aryl Hydrocarbon Hydroxylases
Biological Availability
Biotransformation
Drug Interactions
Drug Resistance
Genetic Variation
Humans
Platelet Aggregation Inhibitors
Platelet Function Tests
Purinergic P2 Receptor Antagonists
Receptors, Purinergic P2
Receptors, Purinergic P2Y12
Ticlopidine
Treatment Failure

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10.1038/nrcardio.2009.29

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title = "The P2Y12 receptor: no active metabolite, no party",

abstract = "Poor responders to clopidogrel have low levels of circulating active metabolite. However, in vitro experiments have shown that blood platelets from poor responders are fully inhibited by the active metabolite of this prodrug. Impaired platelet inhibition reflects inadequate plasma levels of active metabolites, and not differences in platelet P2Y12 receptor function.",

keywords = "Aryl Hydrocarbon Hydroxylases, Biological Availability, Biotransformation, Drug Interactions, Drug Resistance, Genetic Variation, Humans, Platelet Aggregation Inhibitors, Platelet Function Tests, Purinergic P2 Receptor Antagonists, Receptors, Purinergic P2, Receptors, Purinergic P2Y12, Ticlopidine, Treatment Failure, Aryl Hydrocarbon Hydroxylases, Biological Availability, Biotransformation, Drug Interactions, Drug Resistance, Genetic Variation, Humans, Platelet Aggregation Inhibitors, Platelet Function Tests, Purinergic P2 Receptor Antagonists, Receptors, Purinergic P2, Receptors, Purinergic P2Y12, Ticlopidine, Treatment Failure",

author = "Carlo Patrono",

year = "2009",

doi = "10.1038/nrcardio.2009.29",

language = "English",

volume = "6",

pages = "271--272",

journal = "Nature Reviews Cardiology",

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AU - Patrono, Carlo

PY - 2009

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N2 - Poor responders to clopidogrel have low levels of circulating active metabolite. However, in vitro experiments have shown that blood platelets from poor responders are fully inhibited by the active metabolite of this prodrug. Impaired platelet inhibition reflects inadequate plasma levels of active metabolites, and not differences in platelet P2Y12 receptor function.

AB - Poor responders to clopidogrel have low levels of circulating active metabolite. However, in vitro experiments have shown that blood platelets from poor responders are fully inhibited by the active metabolite of this prodrug. Impaired platelet inhibition reflects inadequate plasma levels of active metabolites, and not differences in platelet P2Y12 receptor function.

KW - Aryl Hydrocarbon Hydroxylases

KW - Biological Availability

KW - Biotransformation

KW - Drug Interactions

KW - Drug Resistance

KW - Genetic Variation

KW - Humans

KW - Platelet Aggregation Inhibitors

KW - Platelet Function Tests

KW - Purinergic P2 Receptor Antagonists

KW - Receptors, Purinergic P2

KW - Receptors, Purinergic P2Y12

KW - Ticlopidine

KW - Treatment Failure

KW - Aryl Hydrocarbon Hydroxylases

KW - Biological Availability

KW - Biotransformation

KW - Drug Interactions

KW - Drug Resistance

KW - Genetic Variation

KW - Humans

KW - Platelet Aggregation Inhibitors

KW - Platelet Function Tests

KW - Purinergic P2 Receptor Antagonists

KW - Receptors, Purinergic P2

KW - Receptors, Purinergic P2Y12

KW - Ticlopidine

KW - Treatment Failure

UR - http://hdl.handle.net/10807/7498

U2 - 10.1038/nrcardio.2009.29

DO - 10.1038/nrcardio.2009.29

M3 - Article

SN - 1759-5002

VL - 6

SP - 271

EP - 272

JO - Nature Reviews Cardiology

JF - Nature Reviews Cardiology

ER -

The P2Y12 receptor: no active metabolite, no party

Abstract

Keywords

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