The origin of domestication genes in goats

Zhuqing Zheng, Xihong Wang, Ming Li, Yunjia Li, Zhirui Yang, Xiaolong Wang, Xiangyu Pan, Mian Gong, Yu Zhang, Yingwei Guo, Yu Wang, Jing Liu, Yudong Cai, Qiuming Chen, Moses Okpeku, Moses Okpeku, Moses Okpeku, Licia Colli, Dawei Cai, Kun WangShisheng Huang, Tad S. Sonstegard, Ali Esmailizadeh, Wenguang Zhang, T. Tingting, Yangbin Xu, Naiyi Xu, Yi Yang, Jianlin Han, Jianlin Han, Lei Chen, Joséphine Lesur, Kevin G. Daly, Daniel G. Bradley, Rasmus Heller, Guojie Zhang, Guojie Zhang, Guojie Zhang, Guojie Zhang, Wen Wang, Wen Wang, Wen Wang, Yulin Chen*, Yu Jiang*

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

12 Citazioni (Scopus)


Goat domestication was critical for agriculture and civilization, but its underlying genetic changes and selection regimes remain unclear. Here, we analyze the genomes of worldwide domestic goats, wild caprid species, and historical remains, providing evidence of an ancient introgression event from a West Caucasian tur-like species to the ancestor of domestic goats. One introgressed locus with a strong signature of selection harbors the MUC6 gene, which encodes a gastrointestinally secreted mucin. Experiments revealed that the nearly fixed introgressed haplotype confers enhanced immune resistance to gastrointestinal pathogens. Another locus with a strong signal of selection may be related to behavior. The selected alleles at these two loci emerged in domestic goats at least 7200 and 8100 years ago, respectively, and increased to high frequencies concurrent with the expansion of the ubiquitous modern mitochondrial haplogroup A. Tracking these archaeologically.
Lingua originaleEnglish
pagine (da-a)1-14
Numero di pagine14
RivistaScience advances
Stato di pubblicazionePubblicato - 2020


  • ancient DNA
  • domestication
  • goat
  • whole-genome data


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