The OMERACT ultrasound group: A report from the OMERACT 2016 meeting and perspectives

Maria Antonietta D'Agostino, Lene Terslev, Annamaria Iagnocco, George A.W. Bruyn, Esperanza Naredo, Jelena Vojinovic, Paz Collado, Nemanja Damjanov, Andrew Filer, Georgios Filippou, Stephanie Finzel, Frederique Gandjbakhch, Kei Ikeda, Helen I. Keen, Marion C. Kortekaas, Silvia Magni-Manzoni, Sarah Ohrndorf, Carlos Pineda, Viviana Ravagnani, Bethan RichardsIlfita Sahbudin, Wolfgang A. Schmidt, Heidi J. Siddle, Maria S. Stoenoiu, Marcin Szkudlarek, Nikolay Tzaribachev, Maria-Antonietta D'Agostino

Risultato della ricerca: Contributo in rivistaArticolo in rivista

6 Citazioni (Scopus)

Abstract

Objective: To provide an update from the Outcome Measures in Rheumatology (OMERACT) Ultrasound Working Group on the progress for defining ultrasound (US) minimal disease activity threshold at joint level in rheumatoid arthritis (RA) and for standardization of US application in juvenile idiopathic arthritis (JIA). Methods: For minimal disease activity, healthy controls (HC) and patients with early arthritis (EA) who were naive to disease-modifying antirheumatic drugs were recruited from 2 centers. US was performed of the hands and feet, and scored semiquantitatively (0-3) for synovial hypertrophy (SH) and power Doppler (PD). Synovial effusion (SE) was scored a binary variable. For JIA, a Delphi approach and subsequent validation in static images and patient-based exercises were used to developed preliminary definitions for synovitis and a scoring system. Results: For minimal disease activity, 7% HC had at least 1 joint abnormality versus 30% in the EA group. In HC, the findings of SH and PD were predominantly grade 1 whereas all grades were seen in the EA cohort, but SE was rare. In JIA, synovitis can be diagnosed based on B-mode findings alone because of the presence of physiological vascularization. A semiquantitative scoring system (0-3) for synovitis for both B-mode and Doppler were developed in which the cutoff between Doppler grade 2 and grade 3 was 30%. Conclusion: The first step has been taken to define the threshold for minimal disease activity in RA by US and to define and develop a scoring system for synovitis in JIA. Further steps are planned for the continuous validation of US in these areas. The Journal of Rheumatology
Lingua originaleEnglish
pagine (da-a)1740-1743
Numero di pagine4
RivistaTHE JOURNAL OF RHEUMATOLOGY
Volume44
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Adult
  • Arthritis, Juvenile
  • Arthritis, Rheumatoid
  • Female
  • Foot Joints
  • Hand Joints
  • Humans
  • Juvenile idiopathic arthritis
  • Middle Aged
  • Omeract
  • Reproducibility of Results
  • Rheumatoid arthritis ultrasonography
  • Rheumatology
  • Sensitivity and Specificity
  • Ultrasonography

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