The neutrophil/lymphocyte ratio ≥3.5 is a prognostic marker in diffuse large B-cell lymphoma: a retrospective analysis from the database of the Italian regional network ‘Rete Ematologica del Lazio per i Linfomi’ (RELLI)

Stefan Hohaus, Francesco D'Alo', Eleonora Alma, Silvia Bellesi, Annarosa Cuccaro, Ombretta Annibali, Francesco Marchesi, Maria Cantonetti, Alice Di Rocco, Valeria Tomarchio, Arianna Di Napoli, Sabrina Pelliccia, Roberta Battistini, Paola Anticoli Borza, Elisabetta Abruzzese, Natalia Cenfra, Alessandro Andriani, Cristiano Tesei, Francesca Palombi, Livio PupoLuigi Petrucci, Marco Becilli, Maria Christina Cox

Risultato della ricerca: Contributo in rivistaAbstract

7 Citazioni (Scopus)

Abstract

In solid tumors and lymphomas, the neutrophil/lymphocyte (N/L) ratio at diagnosis has been shown to be a prognostic factor. The aim of our study was to validate the originally reported N/L ratio cut-point of 3.5 in patients with diffuse large B-cell lymphoma (DLBCL) registered in an Italian real-life database. The prognostic role of the N/L ratio at diagnosis on event-free survival (EFS) and overall survival (OS) was assessed in 505 patients with DLBCL. Patients with an N/L ratio <3.5 (n = 249) had a 4-year EFS probability of 76% and OS probability of 86%, significantly higher than the 4 year EFS rate of 48% and OS rate of 64% in patients with N/L ratio ≥3.5 (n = 256, both p<.0001). The N/L ratio was an independent prognostic factor in the multivariate analysis including the IPI score, and could separate patients with a low/intermediate risk IPI (IPI <3).
Lingua originaleEnglish
pagine (da-a)1-9-9
RivistaLEUKEMIA &amp; LYMPHOMA
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • DLBCL
  • N/L ratio
  • R-CHOP
  • cancer
  • lymphoma

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