@article{412200a541124d678013ce43320d0cb5,
title = "The neutrophil/lymphocyte ratio ≥3.5 is a prognostic marker in diffuse large B-cell lymphoma: a retrospective analysis from the database of the Italian regional network {\textquoteleft}Rete Ematologica del Lazio per i Linfomi{\textquoteright} (RELLI)",
abstract = "In solid tumors and lymphomas, the neutrophil/lymphocyte (N/L) ratio at diagnosis has been shown to be a prognostic factor. The aim of our study was to validate the originally reported N/L ratio cut-point of 3.5 in patients with diffuse large B-cell lymphoma (DLBCL) registered in an Italian real-life database. The prognostic role of the N/L ratio at diagnosis on event-free survival (EFS) and overall survival (OS) was assessed in 505 patients with DLBCL. Patients with an N/L ratio <3.5 (n = 249) had a 4-year EFS probability of 76% and OS probability of 86%, significantly higher than the 4 year EFS rate of 48% and OS rate of 64% in patients with N/L ratio ≥3.5 (n = 256, both p<.0001). The N/L ratio was an independent prognostic factor in the multivariate analysis including the IPI score, and could separate patients with a low/intermediate risk IPI (IPI <3).",
keywords = "DLBCL, N/L ratio, R-CHOP, cancer, lymphoma, DLBCL, N/L ratio, R-CHOP, cancer, lymphoma",
author = "Stefan Hohaus and Francesco D'Alo' and Eleonora Alma and Silvia Bellesi and Annarosa Cuccaro and Ombretta Annibali and Francesco Marchesi and Maria Cantonetti and {Di Rocco}, Alice and Valeria Tomarchio and {Di Napoli}, Arianna and Sabrina Pelliccia and Roberta Battistini and {Anticoli Borza}, Paola and Elisabetta Abruzzese and Natalia Cenfra and Alessandro Andriani and Cristiano Tesei and Francesca Palombi and Livio Pupo and Luigi Petrucci and Marco Becilli and Cox, {Maria Christina}",
year = "2019",
doi = "10.1080/10428194.2019.1633628",
language = "English",
pages = "1--9--9",
journal = "Leukemia and Lymphoma",
issn = "1042-8194",
publisher = "Taylor & Francis Limited:Rankine Road, Basingstoke RG24 8PR United Kingdom:011 44 1256 813035, EMAIL: madeline.sims@tandf.co.uk, info@tandf.co.uk, INTERNET: http://www.tandf.co.uk, Fax: 011 44 1256 330245",
}