TY - JOUR
T1 - The neuroprotective and neurogenic effects of neuropeptide Y administration in an animal model of hippocampal neurodegeneration and temporal lobe epilepsy induced by trimethyltin
AU - Corvino, Valentina
AU - Marchese, Elisa
AU - Giannetti, Stefano
AU - Lattanzi, Wanda
AU - Bonvissuto, Davide
AU - Biamonte, Filippo
AU - Michetti, Fabrizio
AU - Geloso, Maria Concetta
AU - Pitocco, Dario
PY - 2012
Y1 - 2012
N2 - The effects of intracerebroventricular administration of neuropeptide Y (NPY), which is believed to play an important role in neuroprotection against excitotoxicity and in the modulation of adult neurogenesis, were evaluated in an animal model of hippocampal neurodegeneration and temporal lobe epilepsy represented by trimethyltin (TMT) intoxication. A single TMT injection (8mg/kg) causes, in the rat brain, massive neuronal death, selectively involving pyramidal neurons, accompanied by glial activation and enhanced hippocampal neurogenesis. Our data indicate that intracerebroventricular administration of exogenous NPY (at the dose of 2μg/2μl, 4 days after TMT-administration), in adult rats, exerts a protective role in regard to TMT-induced hippocampal damage and a proliferative effect on the hippocampal neurogenic niche through the up-regulation of Bcl-2, Bcl2l1, Bdnf, Sox-2, NeuroD1, Noggin and Doublecortin genes, contributing to delineate more clearly the role of NPY in in vivo neurodegenerative processes. © 2012 The Authors Journal of Neurochemistry © 2012 International Society for Neurochemistry.
AB - The effects of intracerebroventricular administration of neuropeptide Y (NPY), which is believed to play an important role in neuroprotection against excitotoxicity and in the modulation of adult neurogenesis, were evaluated in an animal model of hippocampal neurodegeneration and temporal lobe epilepsy represented by trimethyltin (TMT) intoxication. A single TMT injection (8mg/kg) causes, in the rat brain, massive neuronal death, selectively involving pyramidal neurons, accompanied by glial activation and enhanced hippocampal neurogenesis. Our data indicate that intracerebroventricular administration of exogenous NPY (at the dose of 2μg/2μl, 4 days after TMT-administration), in adult rats, exerts a protective role in regard to TMT-induced hippocampal damage and a proliferative effect on the hippocampal neurogenic niche through the up-regulation of Bcl-2, Bcl2l1, Bdnf, Sox-2, NeuroD1, Noggin and Doublecortin genes, contributing to delineate more clearly the role of NPY in in vivo neurodegenerative processes. © 2012 The Authors Journal of Neurochemistry © 2012 International Society for Neurochemistry.
KW - EPILEPSY
KW - HIPPOCAMPAL
KW - NEURODEGENERATION
KW - TRIMETHYLTIN
KW - EPILEPSY
KW - HIPPOCAMPAL
KW - NEURODEGENERATION
KW - TRIMETHYLTIN
UR - http://hdl.handle.net/10807/5616
U2 - 10.1111/j.1471-4159.2012.07770.x
DO - 10.1111/j.1471-4159.2012.07770.x
M3 - Article
SN - 0022-3042
SP - 415
EP - 426
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
ER -