The Multifaceted Roles of MSCs in the Tumor Microenvironment: Interactions With Immune Cells and Exploitation for Therapy

Andrea Papait, Ornella Parolini, Francesca Romana Stefani, Anna Cargnoni, Marta Magatti

Risultato della ricerca: Contributo in rivistaArticolo in rivista

6 Citazioni (Scopus)

Abstract

The tumor microenvironment (TME) plays a critical role in tumorigenesis and is composed of different cellular components, including immune cells and mesenchymal stromal cells (MSCs). In this review, we will discuss MSCs in the TME setting and more specifically their interactions with immune cells and how they can both inhibit (immunosurveillance) and favor (immunoediting) tumor growth. We will also discuss how MSCs are used as a therapeutic strategy in cancer. Due to their unique immunomodulatory properties, MSCs isolated from perinatal tissues are intensely explored as therapeutic interventions in various inflammatory-based disorders with promising results. However, their therapeutic applications in cancer remain for the most part controversial and, importantly, the interactions between administered perinatal MSC and immune cells in the TME remain to be clearly defined.
Lingua originaleEnglish
pagine (da-a)447-N/A
RivistaFrontiers in Cell and Developmental Biology
Volume8
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • cancer
  • immunoediting
  • immunosurveillance
  • inflammation
  • mesenchymal stromal cells
  • perinatal
  • placenta
  • tumor microenvironment

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