TY - JOUR
T1 - The Multi-center Evaluation of the Accuracy of the Contrast MEdium INduced Pd/Pa RaTiO in Predicting FFR (MEMENTOFFR) Study
AU - Trani, Carlo
AU - Burzotta, Francesco
AU - Crea, Filippo
AU - Leone, Antonio Maria
AU - Cialdella, Pio
AU - Basile, Eloisa
AU - Porto, Italo
AU - Aurigemma, Cristina
AU - Rebuzzi, Antonio Giuseppe
AU - Niccoli, Giampaolo
AU - Martin-Reyes, Roberto
AU - Baptista, Sergio B.
AU - Amabile, Nicolas
AU - Raposo, Luis
AU - Franco Pelaez, Juan Antonio
AU - Faustino, Mariana
AU - Abreu, Pedro F.
AU - Slama, Michel S.
AU - Spagnoli, Vincent
AU - Arrieta, Miren Telleria
AU - Amat Santos, Ignacio J.
AU - De La Torre Hernandez, Jose M.
AU - Palop, Ramon Lopez
PY - 2016
Y1 - 2016
N2 - Aims: Adenosine administration is needed for the achievement of maximal hyperaemia fractional flow reserve (FFR) assessment. The objective was to test the accuracy of Pd/Pa ratio registered during submaximal hyperaemia induced by non-ionic contrast medium (contrast FFR [cFFR]) in predicting FFR and comparing it to the performance of resting Pd/Pa in a collaborative registry of 926 patients enrolled in 10 hospitals from four European countries (Italy, Spain, France and Portugal). Methods and results: Resting Pd/Pa, cFFR and FFR were measured in 1,026 coronary stenoses functionally evaluated using commercially available pressure wires. cFFR was obtained after intracoronary injection of contrast medium, while FFR was measured after administration of adenosine. Resting Pd/Pa and cFFR were significantly higher than FFR (0.93±0.05 vs. 0.87±0.08 vs. 0.84±0.08, p<0.001). A strong correlation and a close agreement at Bland-Altman analysis between cFFR and FFR were observed (r=0.90, p<0.001 and 95% CI of disagreement: from-0.042 to 0.11). ROC curve analysis showed an excellent accuracy (89%) of the cFFR cut-off of ?0.85 in predicting an FFR value ?0.80 (AUC 0.95 [95% CI: 0.94-0.96]), significantly better than that observed using resting Pd/Pa (AUC: 0.90, 95% CI: 0.88-0.91; p<0.001). A cFFR/ FFR hybrid approach showed a significantly lower number of lesions requiring adenosine than a resting Pd/ Pa/FFR hybrid approach (22% vs. 44%, p<0.0001). Conclusions: cFFR is accurate in predicting the functional significance of coronary stenosis. This could allow limiting the use of adenosine to obtain FFR to a minority of stenoses with considerable savings of time and costs.
AB - Aims: Adenosine administration is needed for the achievement of maximal hyperaemia fractional flow reserve (FFR) assessment. The objective was to test the accuracy of Pd/Pa ratio registered during submaximal hyperaemia induced by non-ionic contrast medium (contrast FFR [cFFR]) in predicting FFR and comparing it to the performance of resting Pd/Pa in a collaborative registry of 926 patients enrolled in 10 hospitals from four European countries (Italy, Spain, France and Portugal). Methods and results: Resting Pd/Pa, cFFR and FFR were measured in 1,026 coronary stenoses functionally evaluated using commercially available pressure wires. cFFR was obtained after intracoronary injection of contrast medium, while FFR was measured after administration of adenosine. Resting Pd/Pa and cFFR were significantly higher than FFR (0.93±0.05 vs. 0.87±0.08 vs. 0.84±0.08, p<0.001). A strong correlation and a close agreement at Bland-Altman analysis between cFFR and FFR were observed (r=0.90, p<0.001 and 95% CI of disagreement: from-0.042 to 0.11). ROC curve analysis showed an excellent accuracy (89%) of the cFFR cut-off of ?0.85 in predicting an FFR value ?0.80 (AUC 0.95 [95% CI: 0.94-0.96]), significantly better than that observed using resting Pd/Pa (AUC: 0.90, 95% CI: 0.88-0.91; p<0.001). A cFFR/ FFR hybrid approach showed a significantly lower number of lesions requiring adenosine than a resting Pd/ Pa/FFR hybrid approach (22% vs. 44%, p<0.0001). Conclusions: cFFR is accurate in predicting the functional significance of coronary stenosis. This could allow limiting the use of adenosine to obtain FFR to a minority of stenoses with considerable savings of time and costs.
KW - CFFR
KW - Cardiology and Cardiovascular Medicine
KW - Contrast FFR
KW - Contrast mediuminduced Pd/Pa ratio
KW - FFR
KW - Fractional flow reserve
KW - CFFR
KW - Cardiology and Cardiovascular Medicine
KW - Contrast FFR
KW - Contrast mediuminduced Pd/Pa ratio
KW - FFR
KW - Fractional flow reserve
UR - http://hdl.handle.net/10807/98570
UR - http://www.pcronline.com/eurointervention/103rd_issue/volume-12/number-6/115/the-multi-center-evaluation-of-the-accuracy-of-the-contrast-medium-induced-pdpa-ratio-in-predicting-ffr-memento-ffr-study.html
U2 - 10.4244/EIJV12I6A115
DO - 10.4244/EIJV12I6A115
M3 - Article
VL - 12
SP - 708
EP - 715
JO - EuroIntervention
JF - EuroIntervention
SN - 1774-024X
ER -