TY - JOUR
T1 - The Montreux definition of neonatal ARDS: biological and clinical background behind the description of a new entity
AU - De Luca, Daniele
AU - Van Kaam, Anton H
AU - Tingay, David G
AU - Courtney, Sherry E
AU - Danhaive, Olivier
AU - Carnielli, Virgilio P
AU - Zimmermann, Luc J
AU - Kneyber, Martin C J
AU - Tissieres, Pierre
AU - Brierley, Joe
AU - Conti, Giorgio
AU - Pillow, Jane J
AU - Rimensberger, Peter C
PY - 2017
Y1 - 2017
N2 - Acute respiratory distress syndrome (ARDS) is undefined in neonates, despite the long-standing existing formal recognition of ARDS syndrome in later life. We describe the Neonatal ARDS Project: an international, collaborative, multicentre, and multidisciplinary project which aimed to produce an ARDS consensus definition for neonates that is applicable from the perinatal period. The definition was created through discussions between five expert members of the European Society for Paediatric and Neonatal Intensive Care; four experts of the European Society for Paediatric Research; two independent experts from the USA and two from Australia. This Position Paper provides the first consensus definition for neonatal ARDS (called the Montreux definition). We also provide expert consensus that mechanisms causing ARDS in adults and older children—namely complex surfactant dysfunction, lung tissue inflammation, loss of lung volume, increased shunt, and diffuse alveolar damage—are also present in several critical neonatal respiratory disorders.
AB - Acute respiratory distress syndrome (ARDS) is undefined in neonates, despite the long-standing existing formal recognition of ARDS syndrome in later life. We describe the Neonatal ARDS Project: an international, collaborative, multicentre, and multidisciplinary project which aimed to produce an ARDS consensus definition for neonates that is applicable from the perinatal period. The definition was created through discussions between five expert members of the European Society for Paediatric and Neonatal Intensive Care; four experts of the European Society for Paediatric Research; two independent experts from the USA and two from Australia. This Position Paper provides the first consensus definition for neonatal ARDS (called the Montreux definition). We also provide expert consensus that mechanisms causing ARDS in adults and older children—namely complex surfactant dysfunction, lung tissue inflammation, loss of lung volume, increased shunt, and diffuse alveolar damage—are also present in several critical neonatal respiratory disorders.
KW - Pulmonary and Respiratory Medicine
KW - Pulmonary and Respiratory Medicine
UR - http://hdl.handle.net/10807/119176
UR - http://www.elsevier.com/journals/the-lancet-respiratory-medicine/2213-2600
U2 - 10.1016/S2213-2600(17)30214-X
DO - 10.1016/S2213-2600(17)30214-X
M3 - Article
SN - 2213-2600
VL - 5
SP - 657
EP - 666
JO - The Lancet Respiratory Medicine
JF - The Lancet Respiratory Medicine
ER -