The mismatch choice in liver transplantation: a suggestion for the selection of the recipient in relation to the characteristics of the donor.

Alfonso Wolfango Avolio, Salvatore Agnes, Gilda Pepe, Marco Castagneto, Bruno Nardo, Roberto Montalti, Antonino Cavallari

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

24 Citazioni (Scopus)

Abstract

Two hundred seventy-six liver transplants were retrospectively reviewed to analyze 6-month graft survival in relation to the combination of donor quality (standard donor vs nonstandard donor) and risk related to the severity of recipient liver disease low-risk, ie, United Network for Organ Sharing [UNOS] status 3/2b; high-risk, ie, UNOS status 1/2a). The overall 6-month survival rate of 82% was stratified into 4 classes: (1) standard donor to low-risk recipient = 88%; (2) standard donor to high-risk recipient = 86%; (3) nonstandard donor to low-risk recipient = 84%; and (4) nonstandard donor to high-risk recipient = 67%. According to the observed graft survival in the 4 different classes, 2 simulations were performed: the "match simulation" (transplantation of all low-risk recipients using standard donors, and transplantation of all high-risk recipients using nonstandard donors), and the "mismatch simulation" (transplantation of all the high-risk patients using low-risk donors and transplantation of low-risk patients using high-risk donors). The 6-month survival rates, calculated using the match simulation, were 74% and using the mismatch simulation, 84%. The authors suggest that, in the era of marginal donors, the recipient should be selected in relation to the characteristics of the donor according to the mismatch model.
Lingua originaleEnglish
pagine (da-a)2584-2586
Numero di pagine3
RivistaTransplantation Proceedings
Stato di pubblicazionePubblicato - 2005

Keywords

  • DONOR
  • DONOR-RECIPIENT MATCH
  • GRAFT SURVIVAL
  • Liver transplantation
  • OUTCOME
  • PATIENT SURVIVAL
  • RECIPIENT

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