The metabolic role of gut microbiota in the development of nonalcoholic fatty liver disease and cardiovascular disease

Marco Sanduzzi Zamparelli; Debora Compare; Pietro Coccoli; Alba Rocco; Olga Maria Nardone; Giuseppe Marrone; Antonio Gasbarrini; Antonio Grieco; Gerardo Nardone; Luca Miele

doi:10.3390/ijms17081225

The metabolic role of gut microbiota in the development of nonalcoholic fatty liver disease and cardiovascular disease

Marco Sanduzzi Zamparelli, Debora Compare, Pietro Coccoli, Alba Rocco, Olga Maria Nardone, Giuseppe Marrone, Antonio Gasbarrini, Antonio Grieco, Gerardo Nardone^*, Luca Miele

^*Autore corrispondente per questo lavoro

University of Naples Federico II

Risultato della ricerca: Contributo in rivista › Articolo

38 Citazioni (Scopus)

Abstract

The prevalence of metabolic disorders, such as type 2 diabetes (T2D), obesity, and non-alcoholic fatty liver disease (NAFLD), which are common risk factors for cardiovascular disease (CVD), has dramatically increased worldwide over the last decades. Although dietary habit is the main etiologic factor, there is an imperfect correlation between dietary habits and the development of metabolic disease. Recently, research has focused on the role of the microbiome in the development of these disorders. Indeed, gut microbiota is implicated in many metabolic functions and an altered gut microbiota is reported in metabolic disorders. Here we provide evidence linking gut microbiota and metabolic diseases, focusing on the pathogenetic mechanisms underlying this association.

Lingua originale	Inglese
pagine (da-a)	1225-N/A
Rivista	International Journal of Molecular Sciences
Volume	17
Numero di pubblicazione	8
DOI	https://doi.org/10.3390/ijms17081225
Stato di pubblicazione	Pubblicato - 2016

All Science Journal Classification (ASJC) codes

Catalisi
Biologia Molecolare
Spettroscopia
Informatica Applicata
Chimica Fisica e Teorica
Chimica Organica
Chimica Inorganica

Keywords

Cardiovascular disease
Catalysis
Computer Science Applications1707 Computer Vision and Pattern Recognition
Gut microbiota
Inorganic Chemistry
Molecular Biology
NAFLD
Organic Chemistry
Physical and Theoretical Chemistry
Spectroscopy

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

Accesso al documento

10.3390/ijms17081225

Altri file e collegamenti

Cita questo

@article{978b7f213c134e3990b385e384bf5cbb,

title = "The metabolic role of gut microbiota in the development of nonalcoholic fatty liver disease and cardiovascular disease",

abstract = "The prevalence of metabolic disorders, such as type 2 diabetes (T2D), obesity, and non-alcoholic fatty liver disease (NAFLD), which are common risk factors for cardiovascular disease (CVD), has dramatically increased worldwide over the last decades. Although dietary habit is the main etiologic factor, there is an imperfect correlation between dietary habits and the development of metabolic disease. Recently, research has focused on the role of the microbiome in the development of these disorders. Indeed, gut microbiota is implicated in many metabolic functions and an altered gut microbiota is reported in metabolic disorders. Here we provide evidence linking gut microbiota and metabolic diseases, focusing on the pathogenetic mechanisms underlying this association.",

keywords = "Cardiovascular disease, Catalysis, Computer Science Applications1707 Computer Vision and Pattern Recognition, Gut microbiota, Inorganic Chemistry, Molecular Biology, NAFLD, Organic Chemistry, Physical and Theoretical Chemistry, Spectroscopy, Cardiovascular disease, Catalysis, Computer Science Applications1707 Computer Vision and Pattern Recognition, Gut microbiota, Inorganic Chemistry, Molecular Biology, NAFLD, Organic Chemistry, Physical and Theoretical Chemistry, Spectroscopy",

author = "Zamparelli, \{Marco Sanduzzi\} and Debora Compare and Pietro Coccoli and Alba Rocco and Nardone, \{Olga Maria\} and Giuseppe Marrone and Antonio Gasbarrini and Antonio Grieco and Gerardo Nardone and Luca Miele",

year = "2016",

doi = "10.3390/ijms17081225",

language = "English",

volume = "17",

pages = "1225--N/A",

journal = "International Journal of Molecular Sciences",

issn = "1661-6596",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "8",

}

TY - JOUR

T1 - The metabolic role of gut microbiota in the development of nonalcoholic fatty liver disease and cardiovascular disease

AU - Zamparelli, Marco Sanduzzi

AU - Compare, Debora

AU - Coccoli, Pietro

AU - Rocco, Alba

AU - Nardone, Olga Maria

AU - Marrone, Giuseppe

AU - Gasbarrini, Antonio

AU - Grieco, Antonio

AU - Nardone, Gerardo

AU - Miele, Luca

PY - 2016

Y1 - 2016

N2 - The prevalence of metabolic disorders, such as type 2 diabetes (T2D), obesity, and non-alcoholic fatty liver disease (NAFLD), which are common risk factors for cardiovascular disease (CVD), has dramatically increased worldwide over the last decades. Although dietary habit is the main etiologic factor, there is an imperfect correlation between dietary habits and the development of metabolic disease. Recently, research has focused on the role of the microbiome in the development of these disorders. Indeed, gut microbiota is implicated in many metabolic functions and an altered gut microbiota is reported in metabolic disorders. Here we provide evidence linking gut microbiota and metabolic diseases, focusing on the pathogenetic mechanisms underlying this association.

AB - The prevalence of metabolic disorders, such as type 2 diabetes (T2D), obesity, and non-alcoholic fatty liver disease (NAFLD), which are common risk factors for cardiovascular disease (CVD), has dramatically increased worldwide over the last decades. Although dietary habit is the main etiologic factor, there is an imperfect correlation between dietary habits and the development of metabolic disease. Recently, research has focused on the role of the microbiome in the development of these disorders. Indeed, gut microbiota is implicated in many metabolic functions and an altered gut microbiota is reported in metabolic disorders. Here we provide evidence linking gut microbiota and metabolic diseases, focusing on the pathogenetic mechanisms underlying this association.

KW - Cardiovascular disease

KW - Catalysis

KW - Computer Science Applications1707 Computer Vision and Pattern Recognition

KW - Gut microbiota

KW - Inorganic Chemistry

KW - Molecular Biology

KW - NAFLD

KW - Organic Chemistry

KW - Physical and Theoretical Chemistry

KW - Spectroscopy

KW - Cardiovascular disease

KW - Catalysis

KW - Computer Science Applications1707 Computer Vision and Pattern Recognition

KW - Gut microbiota

KW - Inorganic Chemistry

KW - Molecular Biology

KW - NAFLD

KW - Organic Chemistry

KW - Physical and Theoretical Chemistry

KW - Spectroscopy

UR - https://publicatt.unicatt.it/handle/10807/93885

UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85016312583&origin=inward

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85016312583&origin=inward

U2 - 10.3390/ijms17081225

DO - 10.3390/ijms17081225

M3 - Article

SN - 1661-6596

VL - 17

SP - 1225-N/A

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 8

ER -

The metabolic role of gut microbiota in the development of nonalcoholic fatty liver disease and cardiovascular disease

Abstract

All Science Journal Classification (ASJC) codes

Keywords

OSS delle Nazioni Unite

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo