The largest western experience on salvage hepatectomy for recurrent hepatocellular carcinoma: propensity score-matched analysis on behalf of He.RC.O.Le.Study Group

Francesco Ardito; Felice Giuliante; Giuseppe Zimmitti; Francesco Razionale; Maurizio Iaria; Giorgio Bianchi; Federico Fazio; Pasquale Perri; Nicholas Pontarolo; Simone Conci; Matteo Donadon; Matteo Zanello; Quirino Lai; Simone Famularo; Sarah Molfino; Ivano Sciannamea; Luca Fumagalli; Paola Germani; Antonio Floridi; Cecilia Ferrari; Albert Troci; Mauro Zago; Valentina Ferraro; Federica Cipriani; Stefan Patauner; Giuliano La Barba; Maurizio Romano; Giacomo Zanus; Giorgio Ercolani; Antonio Frena; Luca Aldrighetti; Riccardo Memeo; Enrico Pinotti; Michele Crespi; Moh'D Abu Hilal; Guido Griseri; Paola Tarchi; Marco Chiarelli; Adelmo Antonucci; Gian L. Baiocchi; Fabrizio Romano; Massimo Rossi; Elio Jovine; Guido Torzilli; Andrea Ruzzenente; Marcello Maestri; Gian L. Grazi; Alessandro Ferrero; Raffaele Dalla Valle; Mario Giuffrida; Nadia Russolillo; Valerio De Peppo; Matteo Tomasoni; Ivan Marchitelli; Guido Costa; Zoe L. Laureiro; Mauro Scotti; Pietro Calcagno; Davide Cosola; Angelo Franceschi; Alberto Manzoni; Luca Pennacchi; Mauro Montuori; Maria Conticchio; Francesca Ratti; Francesca Notte; Alessandro Cucchetti; Luca Salvador; Pio Corleone; Mattia Garancini; Cristina Ciulli

doi:10.1016/j.hpb.2022.01.001

The largest western experience on salvage hepatectomy for recurrent hepatocellular carcinoma: propensity score-matched analysis on behalf of He.RC.O.Le.Study Group

Francesco Ardito, Felice Giuliante, Giuseppe Zimmitti, Francesco Razionale, Maurizio Iaria, Giorgio Bianchi, Federico Fazio, Pasquale Perri, Nicholas Pontarolo, Simone Conci, Matteo Donadon, Matteo Zanello, Quirino Lai, Simone Famularo, Sarah Molfino, Ivano Sciannamea, Luca Fumagalli, Paola Germani, Antonio Floridi, Cecilia FerrariAlbert Troci, Mauro Zago, Valentina Ferraro, Federica Cipriani, Stefan Patauner, Giuliano La Barba, Maurizio Romano, Giacomo Zanus, Giorgio Ercolani, Antonio Frena, Luca Aldrighetti, Riccardo Memeo, Enrico Pinotti, Michele Crespi, Moh'D Abu Hilal, Guido Griseri, Paola Tarchi, Marco Chiarelli, Adelmo Antonucci, Gian L. Baiocchi, Fabrizio Romano, Massimo Rossi, Elio Jovine, Guido Torzilli, Andrea Ruzzenente, Marcello Maestri, Gian L. Grazi, Alessandro Ferrero, Raffaele Dalla Valle, Mario Giuffrida, Nadia Russolillo, Valerio De Peppo, Matteo Tomasoni, Ivan Marchitelli, Guido Costa, Zoe L. Laureiro, Mauro Scotti, Pietro Calcagno, Davide Cosola, Angelo Franceschi, Alberto Manzoni, Luca Pennacchi, Mauro Montuori, Maria Conticchio, Francesca Ratti, Francesca Notte, Alessandro Cucchetti, Luca Salvador, Pio Corleone, Mattia Garancini, Cristina Ciulli

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

Abstract

Background: We aimed to evaluate, in a large Western cohort, perioperative and long-term oncological outcomes of salvage hepatectomy (SH) for recurrent hepatocellular carcinoma (rHCC) after primary hepatectomy (PH) or locoregional treatments. Methods: Data were collected from the Hepatocarcinoma Recurrence on the Liver Study Group (He.RC.O.Le.S.) Italian Registry. After 1:1 propensity score-matched analysis (PSM), two groups were compared: the PH group (patients submitted to resection for a first HCC) and the SH group (patients resected for intrahepatic rHCC after previous HCC-related treatments). Results: 2689 patients were enrolled. PH included 2339 patients, SH 350. After PSM, 263 patients were selected in each group with major resected nodule median size, intraoperative blood loss and minimally invasive approach significantly lower in the SH group. Long-term outcomes were compared, with no difference in OS and DFS. Univariate and multivariate analyses revealed only microvascular invasion as an independent prognostic factor for OS. Conclusion: SH proved to be equivalent to PH in terms of safety, feasibility and long-term outcomes, consistent with data gathered from East Asia. In the awaiting of reliable treatment-allocating algorithms for rHCC, SH appears to be a suitable alternative in patients fit for surgery, regardless of the previous therapeutic modality implemented.

Lingua originale	English
pagine (da-a)	N/A-N/A
Rivista	HPB
Volume	2022
DOI	https://doi.org/10.1016/j.hpb.2022.01.001
Stato di pubblicazione	Pubblicato - 2022

Keywords

hepatocellular carcinoma
long-term outcome
recurrence
liver resection

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10.1016/j.hpb.2022.01.001

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Ardito, F., Giuliante, F., Zimmitti, G., Razionale, F., Iaria, M., Bianchi, G., Fazio, F., Perri, P., Pontarolo, N., Conci, S., Donadon, M., Zanello, M., Lai, Q., Famularo, S., Molfino, S., Sciannamea, I., Fumagalli, L., Germani, P., Floridi, A., ... Ciulli, C. (2022). The largest western experience on salvage hepatectomy for recurrent hepatocellular carcinoma: propensity score-matched analysis on behalf of He.RC.O.Le.Study Group. HPB, 2022, N/A-N/A. https://doi.org/10.1016/j.hpb.2022.01.001

Ardito, Francesco ; Giuliante, Felice ; Zimmitti, Giuseppe ; Razionale, Francesco ; Iaria, Maurizio ; Bianchi, Giorgio ; Fazio, Federico ; Perri, Pasquale ; Pontarolo, Nicholas ; Conci, Simone ; Donadon, Matteo ; Zanello, Matteo ; Lai, Quirino ; Famularo, Simone ; Molfino, Sarah ; Sciannamea, Ivano ; Fumagalli, Luca ; Germani, Paola ; Floridi, Antonio ; Ferrari, Cecilia ; Troci, Albert ; Zago, Mauro ; Ferraro, Valentina ; Cipriani, Federica ; Patauner, Stefan ; La Barba, Giuliano ; Romano, Maurizio ; Zanus, Giacomo ; Ercolani, Giorgio ; Frena, Antonio ; Aldrighetti, Luca ; Memeo, Riccardo ; Pinotti, Enrico ; Crespi, Michele ; Hilal, Moh'D Abu ; Griseri, Guido ; Tarchi, Paola ; Chiarelli, Marco ; Antonucci, Adelmo ; Baiocchi, Gian L. ; Romano, Fabrizio ; Rossi, Massimo ; Jovine, Elio ; Torzilli, Guido ; Ruzzenente, Andrea ; Maestri, Marcello ; Grazi, Gian L. ; Ferrero, Alessandro ; Dalla Valle, Raffaele ; Giuffrida, Mario ; Russolillo, Nadia ; De Peppo, Valerio ; Tomasoni, Matteo ; Marchitelli, Ivan ; Costa, Guido ; Laureiro, Zoe L. ; Scotti, Mauro ; Calcagno, Pietro ; Cosola, Davide ; Franceschi, Angelo ; Manzoni, Alberto ; Pennacchi, Luca ; Montuori, Mauro ; Conticchio, Maria ; Ratti, Francesca ; Notte, Francesca ; Cucchetti, Alessandro ; Salvador, Luca ; Corleone, Pio ; Garancini, Mattia ; Ciulli, Cristina. / The largest western experience on salvage hepatectomy for recurrent hepatocellular carcinoma: propensity score-matched analysis on behalf of He.RC.O.Le.Study Group. In: HPB. 2022 ; Vol. 2022. pagg. N/A-N/A.

@article{70271fc26fbd410eb41ccdf3985b873f,

title = "The largest western experience on salvage hepatectomy for recurrent hepatocellular carcinoma: propensity score-matched analysis on behalf of He.RC.O.Le.Study Group",

abstract = "Background: We aimed to evaluate, in a large Western cohort, perioperative and long-term oncological outcomes of salvage hepatectomy (SH) for recurrent hepatocellular carcinoma (rHCC) after primary hepatectomy (PH) or locoregional treatments. Methods: Data were collected from the Hepatocarcinoma Recurrence on the Liver Study Group (He.RC.O.Le.S.) Italian Registry. After 1:1 propensity score-matched analysis (PSM), two groups were compared: the PH group (patients submitted to resection for a first HCC) and the SH group (patients resected for intrahepatic rHCC after previous HCC-related treatments). Results: 2689 patients were enrolled. PH included 2339 patients, SH 350. After PSM, 263 patients were selected in each group with major resected nodule median size, intraoperative blood loss and minimally invasive approach significantly lower in the SH group. Long-term outcomes were compared, with no difference in OS and DFS. Univariate and multivariate analyses revealed only microvascular invasion as an independent prognostic factor for OS. Conclusion: SH proved to be equivalent to PH in terms of safety, feasibility and long-term outcomes, consistent with data gathered from East Asia. In the awaiting of reliable treatment-allocating algorithms for rHCC, SH appears to be a suitable alternative in patients fit for surgery, regardless of the previous therapeutic modality implemented.",

keywords = "hepatocellular carcinoma, long-term outcome, recurrence, liver resection, hepatocellular carcinoma, long-term outcome, recurrence, liver resection",

author = "Francesco Ardito and Felice Giuliante and Giuseppe Zimmitti and Francesco Razionale and Maurizio Iaria and Giorgio Bianchi and Federico Fazio and Pasquale Perri and Nicholas Pontarolo and Simone Conci and Matteo Donadon and Matteo Zanello and Quirino Lai and Simone Famularo and Sarah Molfino and Ivano Sciannamea and Luca Fumagalli and Paola Germani and Antonio Floridi and Cecilia Ferrari and Albert Troci and Mauro Zago and Valentina Ferraro and Federica Cipriani and Stefan Patauner and {La Barba}, Giuliano and Maurizio Romano and Giacomo Zanus and Giorgio Ercolani and Antonio Frena and Luca Aldrighetti and Riccardo Memeo and Enrico Pinotti and Michele Crespi and Hilal, {Moh'D Abu} and Guido Griseri and Paola Tarchi and Marco Chiarelli and Adelmo Antonucci and Baiocchi, {Gian L.} and Fabrizio Romano and Massimo Rossi and Elio Jovine and Guido Torzilli and Andrea Ruzzenente and Marcello Maestri and Grazi, {Gian L.} and Alessandro Ferrero and {Dalla Valle}, Raffaele and Mario Giuffrida and Nadia Russolillo and {De Peppo}, Valerio and Matteo Tomasoni and Ivan Marchitelli and Guido Costa and Laureiro, {Zoe L.} and Mauro Scotti and Pietro Calcagno and Davide Cosola and Angelo Franceschi and Alberto Manzoni and Luca Pennacchi and Mauro Montuori and Maria Conticchio and Francesca Ratti and Francesca Notte and Alessandro Cucchetti and Luca Salvador and Pio Corleone and Mattia Garancini and Cristina Ciulli",

year = "2022",

doi = "10.1016/j.hpb.2022.01.001",

language = "English",

volume = "2022",

pages = "N/A--N/A",

journal = "HPB",

issn = "1365-182X",

publisher = "Martin Dunitz Limited:The Livery House, 7-9 Pratt Street, London NW1 0AE United Kingdom:011 44 20 74822202, INTERNET: http://www.dunitz.co.uk, Fax: 011 44 20 72670159",

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Ardito, F , Giuliante, F, Zimmitti, G, Razionale, F, Iaria, M, Bianchi, G, Fazio, F, Perri, P, Pontarolo, N, Conci, S, Donadon, M, Zanello, M, Lai, Q, Famularo, S, Molfino, S, Sciannamea, I, Fumagalli, L, Germani, P, Floridi, A, Ferrari, C, Troci, A, Zago, M, Ferraro, V, Cipriani, F, Patauner, S, La Barba, G, Romano, M, Zanus, G, Ercolani, G, Frena, A, Aldrighetti, L, Memeo, R, Pinotti, E, Crespi, M, Hilal, MDA, Griseri, G, Tarchi, P, Chiarelli, M, Antonucci, A, Baiocchi, GL, Romano, F, Rossi, M, Jovine, E, Torzilli, G, Ruzzenente, A, Maestri, M, Grazi, GL, Ferrero, A, Dalla Valle, R, Giuffrida, M, Russolillo, N, De Peppo, V, Tomasoni, M, Marchitelli, I, Costa, G, Laureiro, ZL, Scotti, M, Calcagno, P, Cosola, D, Franceschi, A, Manzoni, A, Pennacchi, L, Montuori, M, Conticchio, M, Ratti, F, Notte, F, Cucchetti, A, Salvador, L, Corleone, P, Garancini, M & Ciulli, C 2022, 'The largest western experience on salvage hepatectomy for recurrent hepatocellular carcinoma: propensity score-matched analysis on behalf of He.RC.O.Le.Study Group', HPB, vol. 2022, pagg. N/A-N/A. https://doi.org/10.1016/j.hpb.2022.01.001

The largest western experience on salvage hepatectomy for recurrent hepatocellular carcinoma: propensity score-matched analysis on behalf of He.RC.O.Le.Study Group. / Ardito, Francesco ; Giuliante, Felice; Zimmitti, Giuseppe; Razionale, Francesco; Iaria, Maurizio; Bianchi, Giorgio; Fazio, Federico; Perri, Pasquale; Pontarolo, Nicholas; Conci, Simone; Donadon, Matteo; Zanello, Matteo; Lai, Quirino; Famularo, Simone; Molfino, Sarah; Sciannamea, Ivano; Fumagalli, Luca; Germani, Paola; Floridi, Antonio; Ferrari, Cecilia; Troci, Albert; Zago, Mauro; Ferraro, Valentina; Cipriani, Federica; Patauner, Stefan; La Barba, Giuliano; Romano, Maurizio; Zanus, Giacomo; Ercolani, Giorgio; Frena, Antonio; Aldrighetti, Luca; Memeo, Riccardo; Pinotti, Enrico; Crespi, Michele; Hilal, Moh'D Abu; Griseri, Guido; Tarchi, Paola; Chiarelli, Marco; Antonucci, Adelmo; Baiocchi, Gian L.; Romano, Fabrizio; Rossi, Massimo; Jovine, Elio; Torzilli, Guido; Ruzzenente, Andrea; Maestri, Marcello; Grazi, Gian L.; Ferrero, Alessandro; Dalla Valle, Raffaele; Giuffrida, Mario; Russolillo, Nadia; De Peppo, Valerio; Tomasoni, Matteo; Marchitelli, Ivan; Costa, Guido; Laureiro, Zoe L.; Scotti, Mauro; Calcagno, Pietro; Cosola, Davide; Franceschi, Angelo; Manzoni, Alberto; Pennacchi, Luca; Montuori, Mauro; Conticchio, Maria; Ratti, Francesca; Notte, Francesca; Cucchetti, Alessandro; Salvador, Luca; Corleone, Pio; Garancini, Mattia; Ciulli, Cristina.

In: HPB, Vol. 2022, 2022, pag. N/A-N/A.

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

TY - JOUR

T1 - The largest western experience on salvage hepatectomy for recurrent hepatocellular carcinoma: propensity score-matched analysis on behalf of He.RC.O.Le.Study Group

AU - Ardito, Francesco

AU - Giuliante, Felice

AU - Zimmitti, Giuseppe

AU - Razionale, Francesco

AU - Iaria, Maurizio

AU - Bianchi, Giorgio

AU - Fazio, Federico

AU - Perri, Pasquale

AU - Pontarolo, Nicholas

AU - Conci, Simone

AU - Donadon, Matteo

AU - Zanello, Matteo

AU - Lai, Quirino

AU - Famularo, Simone

AU - Molfino, Sarah

AU - Sciannamea, Ivano

AU - Fumagalli, Luca

AU - Germani, Paola

AU - Floridi, Antonio

AU - Ferrari, Cecilia

AU - Troci, Albert

AU - Zago, Mauro

AU - Ferraro, Valentina

AU - Cipriani, Federica

AU - Patauner, Stefan

AU - La Barba, Giuliano

AU - Romano, Maurizio

AU - Zanus, Giacomo

AU - Ercolani, Giorgio

AU - Frena, Antonio

AU - Aldrighetti, Luca

AU - Memeo, Riccardo

AU - Pinotti, Enrico

AU - Crespi, Michele

AU - Hilal, Moh'D Abu

AU - Griseri, Guido

AU - Tarchi, Paola

AU - Chiarelli, Marco

AU - Antonucci, Adelmo

AU - Baiocchi, Gian L.

AU - Romano, Fabrizio

AU - Rossi, Massimo

AU - Jovine, Elio

AU - Torzilli, Guido

AU - Ruzzenente, Andrea

AU - Maestri, Marcello

AU - Grazi, Gian L.

AU - Ferrero, Alessandro

AU - Dalla Valle, Raffaele

AU - Giuffrida, Mario

AU - Russolillo, Nadia

AU - De Peppo, Valerio

AU - Tomasoni, Matteo

AU - Marchitelli, Ivan

AU - Costa, Guido

AU - Laureiro, Zoe L.

AU - Scotti, Mauro

AU - Calcagno, Pietro

AU - Cosola, Davide

AU - Franceschi, Angelo

AU - Manzoni, Alberto

AU - Pennacchi, Luca

AU - Montuori, Mauro

AU - Conticchio, Maria

AU - Ratti, Francesca

AU - Notte, Francesca

AU - Cucchetti, Alessandro

AU - Salvador, Luca

AU - Corleone, Pio

AU - Garancini, Mattia

AU - Ciulli, Cristina

PY - 2022

Y1 - 2022

N2 - Background: We aimed to evaluate, in a large Western cohort, perioperative and long-term oncological outcomes of salvage hepatectomy (SH) for recurrent hepatocellular carcinoma (rHCC) after primary hepatectomy (PH) or locoregional treatments. Methods: Data were collected from the Hepatocarcinoma Recurrence on the Liver Study Group (He.RC.O.Le.S.) Italian Registry. After 1:1 propensity score-matched analysis (PSM), two groups were compared: the PH group (patients submitted to resection for a first HCC) and the SH group (patients resected for intrahepatic rHCC after previous HCC-related treatments). Results: 2689 patients were enrolled. PH included 2339 patients, SH 350. After PSM, 263 patients were selected in each group with major resected nodule median size, intraoperative blood loss and minimally invasive approach significantly lower in the SH group. Long-term outcomes were compared, with no difference in OS and DFS. Univariate and multivariate analyses revealed only microvascular invasion as an independent prognostic factor for OS. Conclusion: SH proved to be equivalent to PH in terms of safety, feasibility and long-term outcomes, consistent with data gathered from East Asia. In the awaiting of reliable treatment-allocating algorithms for rHCC, SH appears to be a suitable alternative in patients fit for surgery, regardless of the previous therapeutic modality implemented.

AB - Background: We aimed to evaluate, in a large Western cohort, perioperative and long-term oncological outcomes of salvage hepatectomy (SH) for recurrent hepatocellular carcinoma (rHCC) after primary hepatectomy (PH) or locoregional treatments. Methods: Data were collected from the Hepatocarcinoma Recurrence on the Liver Study Group (He.RC.O.Le.S.) Italian Registry. After 1:1 propensity score-matched analysis (PSM), two groups were compared: the PH group (patients submitted to resection for a first HCC) and the SH group (patients resected for intrahepatic rHCC after previous HCC-related treatments). Results: 2689 patients were enrolled. PH included 2339 patients, SH 350. After PSM, 263 patients were selected in each group with major resected nodule median size, intraoperative blood loss and minimally invasive approach significantly lower in the SH group. Long-term outcomes were compared, with no difference in OS and DFS. Univariate and multivariate analyses revealed only microvascular invasion as an independent prognostic factor for OS. Conclusion: SH proved to be equivalent to PH in terms of safety, feasibility and long-term outcomes, consistent with data gathered from East Asia. In the awaiting of reliable treatment-allocating algorithms for rHCC, SH appears to be a suitable alternative in patients fit for surgery, regardless of the previous therapeutic modality implemented.

KW - hepatocellular carcinoma

KW - long-term outcome

KW - recurrence

KW - liver resection

KW - hepatocellular carcinoma

KW - long-term outcome

KW - recurrence

KW - liver resection

UR - http://hdl.handle.net/10807/199164

U2 - 10.1016/j.hpb.2022.01.001

DO - 10.1016/j.hpb.2022.01.001

M3 - Article

VL - 2022

SP - N/A-N/A

JO - HPB

JF - HPB

SN - 1365-182X

ER -

The largest western experience on salvage hepatectomy for recurrent hepatocellular carcinoma: propensity score-matched analysis on behalf of He.RC.O.Le.Study Group

Abstract

Keywords

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