The Italian experience on paediatric liver transplantation: 1988-1999 report

Maurizio Pompili, Gian Ludovico Rapaccini, Antonio Gasbarrini, Giovanni Battista Gasbarrini, Samuela Beccaria, Vg Mirante, S Fagiuoli, G Leandro, R Naccarato, L Pagliaro, M Rizzetto

Risultato della ricerca: Contributo in rivistaArticolo in rivista

3 Citazioni (Scopus)

Abstract

BACKGROUND: Liver transplantation is the treatment of choice for end-stage liver disease in both adult and paediatric patients. The Italian experience in paediatric liver transplantation during the period 1988-1999 is reported herein. PATIENTS AND METHODS: This report concerns 228 liver transplantations performed in 207 patients (100 male, 107 female, mean age 5.1+/-4.4 years) in 11 Italian centres. The mean waiting time on the transplantation list was 6.1+/-8.9 months and the main indications for the procedure were biliary atresia, inborn metabolic disorders, liver cirrhosis, liver neoplasms, Alagille syndrome, and fulminant hepatic failure. RESULTS: The cumulative survival rate was 77%, 76%, 73%, and 71% at 1, 3, 5, and 7 years. The overall prevalence of acute rejection was 54%. Survival was significantly affected by re-transplantation (p=0.0002), by United Network for Organ Sharing 4 status at transplantation (p=0.016), and, among the indications for the procedure, by fulminant hepatic failure (p=0.004). Fifty patients (24%) died during the observation period. The main causes of death were primary non-function of the graft and sepsis CONCLUSIONS: This study shows that liver transplantation in paediatric age, in Italy, is an effective procedure providing a 5-year survival rate comparable to that attained in the largest published series.
Lingua originaleEnglish
pagine (da-a)649-655
Numero di pagine7
RivistaDIGESTIVE AND LIVER DISEASE
Volume34
Stato di pubblicazionePubblicato - 2002

Keywords

  • Cause of Death
  • Child
  • Child, Preschool
  • Female
  • Graft Rejection
  • Humans
  • Infant
  • Italy
  • Liver Diseases
  • Liver Transplantation
  • Male
  • Prevalence
  • Survival Rate

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