The interplay of extracellular vesicles in the pathogenesis of metabolic impairment and type 2 diabetes

Lorenzo Carciero; Gianfranco Di Giuseppe; Eleonora Di Piazza; Erfan Parand; Laura Soldovieri; Gea Ciccarelli; Michela Brunetti; Antonio Gasbarrini; Enrico C Nista; Giovambattista Pani; Alfredo Pontecorvi; Andrea Giaccari; Teresa Mezza

doi:10.1016/j.diabres.2024.111837

The interplay of extracellular vesicles in the pathogenesis of metabolic impairment and type 2 diabetes

Lorenzo Carciero
, Gianfranco Di Giuseppe
, Eleonora Di Piazza
, Erfan Parand
, Laura Soldovieri
, Gea Ciccarelli
, Michela Brunetti
, Antonio Gasbarrini
, Enrico C Nista
, Giovambattista Pani
, Alfredo Pontecorvi
, Andrea Giaccari
, Teresa Mezza^*

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo

Abstract

The pathogenesis of type 2 diabetes (T2D) involves dysfunction in multiple organs, including the liver, muscle, adipose tissue, and pancreas, leading to insulin resistance and β cell failure. Recent studies highlight the significant role of extracellular vesicles (EVs) in mediating inter-organ communication in T2D. This review investigates the role of EVs, focusing on their presence and biological significance in human plasma and tissues affected by T2D. We explore specific EV cargo, such as miRNAs and proteins, which affect insulin signaling and glucose metabolism, emphasizing their potential as biomarkers. By highlighting the diagnostic and therapeutic potential of EVs, we aim to provide new insights into their role in early detection, disease monitoring, and innovative treatment strategies for T2D.

Lingua originale	Inglese
pagine (da-a)	N/A-N/A
Rivista	Diabetes Research and Clinical Practice
Volume	216
Numero di pubblicazione	n/a
DOI	https://doi.org/10.1016/j.diabres.2024.111837
Stato di pubblicazione	Pubblicato - 2024

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

SDG 3 Salute e benessere

All Science Journal Classification (ASJC) codes

Medicina Interna
Endocrinologia, Diabete e Metabolismo
Endocrinologia

Keywords

Exosomes
Extracellular vesicles
Metabolic disease
Microvesicles
Pancreatic islets
Type 2 diabetes

Accesso al documento

10.1016/j.diabres.2024.111837

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Carciero, L., Di Giuseppe, G., Di Piazza, E., Parand, E., Soldovieri, L., Ciccarelli, G., Brunetti, M., Gasbarrini, A., Nista, E. C., Pani, G., Pontecorvi, A., Giaccari, A., & Mezza, T. (2024). The interplay of extracellular vesicles in the pathogenesis of metabolic impairment and type 2 diabetes. Diabetes Research and Clinical Practice, 216(n/a), N/A-N/A. https://doi.org/10.1016/j.diabres.2024.111837

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title = "The interplay of extracellular vesicles in the pathogenesis of metabolic impairment and type 2 diabetes",

abstract = "The pathogenesis of type 2 diabetes (T2D) involves dysfunction in multiple organs, including the liver, muscle, adipose tissue, and pancreas, leading to insulin resistance and β cell failure. Recent studies highlight the significant role of extracellular vesicles (EVs) in mediating inter-organ communication in T2D. This review investigates the role of EVs, focusing on their presence and biological significance in human plasma and tissues affected by T2D. We explore specific EV cargo, such as miRNAs and proteins, which affect insulin signaling and glucose metabolism, emphasizing their potential as biomarkers. By highlighting the diagnostic and therapeutic potential of EVs, we aim to provide new insights into their role in early detection, disease monitoring, and innovative treatment strategies for T2D.",

keywords = "Exosomes, Extracellular vesicles, Metabolic disease, Microvesicles, Pancreatic islets, Type 2 diabetes, Exosomes, Extracellular vesicles, Metabolic disease, Microvesicles, Pancreatic islets, Type 2 diabetes",

author = "Lorenzo Carciero and \{Di Giuseppe\}, Gianfranco and \{Di Piazza\}, Eleonora and Erfan Parand and Laura Soldovieri and Gea Ciccarelli and Michela Brunetti and Antonio Gasbarrini and Nista, \{Enrico C\} and Giovambattista Pani and Alfredo Pontecorvi and Andrea Giaccari and Teresa Mezza",

year = "2024",

doi = "10.1016/j.diabres.2024.111837",

language = "English",

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pages = "N/A--N/A",

journal = "Diabetes Research and Clinical Practice",

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Carciero, L, Di Giuseppe, G, Di Piazza, E, Parand, E, Soldovieri, L, Ciccarelli, G, Brunetti, M, Gasbarrini, A, Nista, EC, Pani, G , Pontecorvi, A , Giaccari, A & Mezza, T 2024, 'The interplay of extracellular vesicles in the pathogenesis of metabolic impairment and type 2 diabetes', Diabetes Research and Clinical Practice, vol. 216, n. n/a, pagg. N/A-N/A. https://doi.org/10.1016/j.diabres.2024.111837

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AU - Carciero, Lorenzo

AU - Di Giuseppe, Gianfranco

AU - Di Piazza, Eleonora

AU - Parand, Erfan

AU - Soldovieri, Laura

AU - Ciccarelli, Gea

AU - Brunetti, Michela

AU - Gasbarrini, Antonio

AU - Nista, Enrico C

AU - Pani, Giovambattista

AU - Pontecorvi, Alfredo

AU - Giaccari, Andrea

AU - Mezza, Teresa

PY - 2024

Y1 - 2024

N2 - The pathogenesis of type 2 diabetes (T2D) involves dysfunction in multiple organs, including the liver, muscle, adipose tissue, and pancreas, leading to insulin resistance and β cell failure. Recent studies highlight the significant role of extracellular vesicles (EVs) in mediating inter-organ communication in T2D. This review investigates the role of EVs, focusing on their presence and biological significance in human plasma and tissues affected by T2D. We explore specific EV cargo, such as miRNAs and proteins, which affect insulin signaling and glucose metabolism, emphasizing their potential as biomarkers. By highlighting the diagnostic and therapeutic potential of EVs, we aim to provide new insights into their role in early detection, disease monitoring, and innovative treatment strategies for T2D.

AB - The pathogenesis of type 2 diabetes (T2D) involves dysfunction in multiple organs, including the liver, muscle, adipose tissue, and pancreas, leading to insulin resistance and β cell failure. Recent studies highlight the significant role of extracellular vesicles (EVs) in mediating inter-organ communication in T2D. This review investigates the role of EVs, focusing on their presence and biological significance in human plasma and tissues affected by T2D. We explore specific EV cargo, such as miRNAs and proteins, which affect insulin signaling and glucose metabolism, emphasizing their potential as biomarkers. By highlighting the diagnostic and therapeutic potential of EVs, we aim to provide new insights into their role in early detection, disease monitoring, and innovative treatment strategies for T2D.

KW - Exosomes

KW - Extracellular vesicles

KW - Metabolic disease

KW - Microvesicles

KW - Pancreatic islets

KW - Type 2 diabetes

KW - Exosomes

KW - Extracellular vesicles

KW - Metabolic disease

KW - Microvesicles

KW - Pancreatic islets

KW - Type 2 diabetes

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JO - Diabetes Research and Clinical Practice

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The interplay of extracellular vesicles in the pathogenesis of metabolic impairment and type 2 diabetes

Abstract

OSS delle Nazioni Unite

All Science Journal Classification (ASJC) codes

Keywords

Accesso al documento

Altri file e collegamenti

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