TY - JOUR
T1 - The interplay of extracellular vesicles in the pathogenesis of metabolic impairment and type 2 diabetes
AU - Carciero, Lorenzo
AU - Di Giuseppe, Gianfranco
AU - Di Piazza, Eleonora
AU - Parand, Erfan
AU - Soldovieri, Laura
AU - Ciccarelli, Gea
AU - Brunetti, Michela
AU - Gasbarrini, Antonio
AU - Nista, Enrico Celestino
AU - Pani, Giovambattista
AU - Pontecorvi, Alfredo
AU - Giaccari, Andrea
AU - Mezza, Teresa
PY - 2024
Y1 - 2024
N2 - The pathogenesis of type 2 diabetes (T2D) involves dysfunction in multiple organs, including the liver, muscle, adipose tissue, and pancreas, leading to insulin resistance and β cell failure. Recent studies highlight the significant role of extracellular vesicles (EVs) in mediating inter-organ communication in T2D. This review investigates the role of EVs, focusing on their presence and biological significance in human plasma and tissues affected by T2D. We explore specific EV cargo, such as miRNAs and proteins, which affect insulin signaling and glucose metabolism, emphasizing their potential as biomarkers. By highlighting the diagnostic and therapeutic potential of EVs, we aim to provide new insights into their role in early detection, disease monitoring, and innovative treatment strategies for T2D.
AB - The pathogenesis of type 2 diabetes (T2D) involves dysfunction in multiple organs, including the liver, muscle, adipose tissue, and pancreas, leading to insulin resistance and β cell failure. Recent studies highlight the significant role of extracellular vesicles (EVs) in mediating inter-organ communication in T2D. This review investigates the role of EVs, focusing on their presence and biological significance in human plasma and tissues affected by T2D. We explore specific EV cargo, such as miRNAs and proteins, which affect insulin signaling and glucose metabolism, emphasizing their potential as biomarkers. By highlighting the diagnostic and therapeutic potential of EVs, we aim to provide new insights into their role in early detection, disease monitoring, and innovative treatment strategies for T2D.
KW - Exosomes
KW - Extracellular vesicles
KW - Type 2 diabetes
KW - Microvesicles
KW - Pancreatic islets
KW - Metabolic disease
KW - Exosomes
KW - Extracellular vesicles
KW - Type 2 diabetes
KW - Microvesicles
KW - Pancreatic islets
KW - Metabolic disease
UR - http://hdl.handle.net/10807/303685
U2 - 10.1016/j.diabres.2024.111837
DO - 10.1016/j.diabres.2024.111837
M3 - Article
SN - 0168-8227
VL - 216
SP - N/A-N/A
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
ER -
