The Interplay between CD27dull and CD27bright B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory

Ola Grimsholm; Eva Piano Mortari; Alexey N. Davydov; Mikhail Shugay; Anna S. Obraztsova; Chiara Bocci; Emiliano Marasco; Valentina Marcellini; Alaitz Aranburu; Chiara Farroni; Domenico Alessandro Silvestris; Cristina Cristofoletti; Ezio Giorda; Marco Scarsella; Simona Cascioli; Sabina Barresi; Vassilios Lougaris; Alessandro Plebani; Caterina Cancrini; Andrea Finocchi; Viviana Moschese; Diletta Valentini; Cristina Vallone; Fabrizio Signore; Giovanni De Vincentiis; Salvatore Zaffina; Giandomenico Russo; Angela Gallo; Franco Locatelli; Alberto E. Tozzi; Marco Tartaglia; Dmitriy M. Chudakov; Rita Carsetti

doi:10.1016/j.celrep.2020.02.022

The Interplay between CD27dull and CD27bright B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory

Ola Grimsholm, Eva Piano Mortari, Alexey N. Davydov, Mikhail Shugay, Anna S. Obraztsova, Chiara Bocci, Emiliano Marasco, Valentina Marcellini, Alaitz Aranburu, Chiara Farroni, Domenico Alessandro Silvestris, Cristina Cristofoletti, Ezio Giorda, Marco Scarsella, Simona Cascioli, Sabina Barresi, Vassilios Lougaris, Alessandro Plebani, Caterina Cancrini, Andrea FinocchiViviana Moschese, Diletta Valentini, Cristina Vallone, Fabrizio Signore, Giovanni De Vincentiis, Salvatore Zaffina, Giandomenico Russo, Angela Gallo, Franco Locatelli, Alberto E. Tozzi, Marco Tartaglia, Dmitriy M. Chudakov, Rita Carsetti

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

Grimsholm et al. show that CD27dull and CD27bright represent sequential MBC developmental stages. T cell- and germinal center (GC)-independent CD27dull MBCs are the plastic source of strongly selected and GC-dependent CD27bright MBCs. CD27dull MBCs, able to expand and differentiate in response to change, ensure stability and flexibility of human B cell memory.

Lingua originale	English
pagine (da-a)	2963-2977
Numero di pagine	15
Rivista	Cell Reports
Volume	30
DOI	https://doi.org/10.1016/j.celrep.2020.02.022
Stato di pubblicazione	Pubblicato - 2020

Keywords

aging
CD27
germinal center
immunodeficiency
VH repertoire
memory B cells
pregnancy
spleen
vaccine
immunological memory

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Grimsholm, O., Piano Mortari, E., Davydov, A. N., Shugay, M., Obraztsova, A. S., Bocci, C., Marasco, E., Marcellini, V., Aranburu, A., Farroni, C., Silvestris, D. A., Cristofoletti, C., Giorda, E., Scarsella, M., Cascioli, S., Barresi, S., Lougaris, V., Plebani, A., Cancrini, C., ... Carsetti, R. (2020). The Interplay between CD27dull and CD27bright B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory. Cell Reports, 30, 2963-2977. https://doi.org/10.1016/j.celrep.2020.02.022

@article{df6a7168d0244fc0baec20ea68d06eac,

title = "The Interplay between CD27dull and CD27bright B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory",

abstract = "Grimsholm et al. show that CD27dull and CD27bright represent sequential MBC developmental stages. T cell- and germinal center (GC)-independent CD27dull MBCs are the plastic source of strongly selected and GC-dependent CD27bright MBCs. CD27dull MBCs, able to expand and differentiate in response to change, ensure stability and flexibility of human B cell memory.",

keywords = "aging, CD27, germinal center, immunodeficiency, VH repertoire, memory B cells, pregnancy, spleen, vaccine, immunological memory, aging, CD27, germinal center, immunodeficiency, VH repertoire, memory B cells, pregnancy, spleen, vaccine, immunological memory",

author = "Ola Grimsholm and {Piano Mortari}, Eva and Davydov, {Alexey N.} and Mikhail Shugay and Obraztsova, {Anna S.} and Chiara Bocci and Emiliano Marasco and Valentina Marcellini and Alaitz Aranburu and Chiara Farroni and Silvestris, {Domenico Alessandro} and Cristina Cristofoletti and Ezio Giorda and Marco Scarsella and Simona Cascioli and Sabina Barresi and Vassilios Lougaris and Alessandro Plebani and Caterina Cancrini and Andrea Finocchi and Viviana Moschese and Diletta Valentini and Cristina Vallone and Fabrizio Signore and {De Vincentiis}, Giovanni and Salvatore Zaffina and Giandomenico Russo and Angela Gallo and Franco Locatelli and Tozzi, {Alberto E.} and Marco Tartaglia and Chudakov, {Dmitriy M.} and Rita Carsetti",

year = "2020",

doi = "10.1016/j.celrep.2020.02.022",

language = "English",

volume = "30",

pages = "2963--2977",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Elsevier B.V.",

}

Grimsholm, O, Piano Mortari, E, Davydov, AN, Shugay, M, Obraztsova, AS, Bocci, C, Marasco, E, Marcellini, V, Aranburu, A, Farroni, C, Silvestris, DA, Cristofoletti, C, Giorda, E, Scarsella, M, Cascioli, S, Barresi, S, Lougaris, V, Plebani, A, Cancrini, C, Finocchi, A, Moschese, V, Valentini, D, Vallone, C, Signore, F, De Vincentiis, G, Zaffina, S, Russo, G, Gallo, A, Locatelli, F, Tozzi, AE, Tartaglia, M, Chudakov, DM & Carsetti, R 2020, 'The Interplay between CD27dull and CD27bright B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory', Cell Reports, vol. 30, pagg. 2963-2977. https://doi.org/10.1016/j.celrep.2020.02.022

TY - JOUR

T1 - The Interplay between CD27dull and CD27bright B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory

AU - Grimsholm, Ola

AU - Piano Mortari, Eva

AU - Davydov, Alexey N.

AU - Shugay, Mikhail

AU - Obraztsova, Anna S.

AU - Bocci, Chiara

AU - Marasco, Emiliano

AU - Marcellini, Valentina

AU - Aranburu, Alaitz

AU - Farroni, Chiara

AU - Silvestris, Domenico Alessandro

AU - Cristofoletti, Cristina

AU - Giorda, Ezio

AU - Scarsella, Marco

AU - Cascioli, Simona

AU - Barresi, Sabina

AU - Lougaris, Vassilios

AU - Plebani, Alessandro

AU - Cancrini, Caterina

AU - Finocchi, Andrea

AU - Moschese, Viviana

AU - Valentini, Diletta

AU - Vallone, Cristina

AU - Signore, Fabrizio

AU - De Vincentiis, Giovanni

AU - Zaffina, Salvatore

AU - Russo, Giandomenico

AU - Gallo, Angela

AU - Locatelli, Franco

AU - Tozzi, Alberto E.

AU - Tartaglia, Marco

AU - Chudakov, Dmitriy M.

AU - Carsetti, Rita

PY - 2020

Y1 - 2020

N2 - Grimsholm et al. show that CD27dull and CD27bright represent sequential MBC developmental stages. T cell- and germinal center (GC)-independent CD27dull MBCs are the plastic source of strongly selected and GC-dependent CD27bright MBCs. CD27dull MBCs, able to expand and differentiate in response to change, ensure stability and flexibility of human B cell memory.

AB - Grimsholm et al. show that CD27dull and CD27bright represent sequential MBC developmental stages. T cell- and germinal center (GC)-independent CD27dull MBCs are the plastic source of strongly selected and GC-dependent CD27bright MBCs. CD27dull MBCs, able to expand and differentiate in response to change, ensure stability and flexibility of human B cell memory.

KW - aging

KW - CD27

KW - germinal center

KW - immunodeficiency

KW - VH repertoire

KW - memory B cells

KW - pregnancy

KW - spleen

KW - vaccine

KW - immunological memory

KW - aging

KW - CD27

KW - germinal center

KW - immunodeficiency

KW - VH repertoire

KW - memory B cells

KW - pregnancy

KW - spleen

KW - vaccine

KW - immunological memory

UR - http://hdl.handle.net/10807/229748

U2 - 10.1016/j.celrep.2020.02.022

DO - 10.1016/j.celrep.2020.02.022

M3 - Article

SN - 2211-1247

VL - 30

SP - 2963

EP - 2977

JO - Cell Reports

JF - Cell Reports

ER -

The Interplay between CD27dull and CD27bright B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory

Abstract

Keywords

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