Background: Malnutrition in liver surgery is correlated with higher postoperative complications and longer length of hospital stay (LOHS), the same items that ERAS programs try to optimize. However, to date, standardized dietary protocols have not been defined within ERAS programs. Aim of this study was to evaluate the impact on LOHS and postoperative complications, of a personalized nutritional protocol (NutriCatt) with diet and oral branched-chain amino acid (BCAA) supplementation, adopted within the ERAS program. Methods: 1960 consecutive liver resections were performed from January 2000 to September 2018. Exclusion criteria: perihilar cholangiocarcinoma, simultaneous colorectal and liver resections. Four groups for analysis: resections before 2009 (1st period); from 2009 to 2016 (2nd period, including laparoscopic resections); between 2016 and September 2017 (ERAS); after September 2017 (ERAS + NutriCatt). Results: LOHS declined (p < 0.0001), from a median of 10 days (1st period) to 8, 7 and 6 in 2nd period, ERAS and ERAS + NutriCatt groups, respectively. At multivariable analysis for risk of LOHS > 8 days, the 2nd period, ERAS and ERAS + NutriCatt groups showed a protective effect. These results were confirmed for both minor and major resections. LOHS was significantly lower in ERAS + Nutricatt group than in ERAS group, without increasing risk of postoperative complications, although the rate of laparoscopic resections was similar in these two groups and complexity of liver resections was significantly higher in the last period. Conclusions: Adoption of a personalized nutritional protocol with BCAA supplementation within the ERAS program for liver resections was a safe and effective approach that may impact on reducing the LOHS.
Lingua originaleEnglish
pagine (da-a)681-691
Numero di pagine11
RivistaUpdates in Surgery
Stato di pubblicazionePubblicato - 2020


  • Amino Acids, Branched-Chain
  • Diet
  • Dietary Supplements
  • ERAS
  • Enhanced Recovery After Surgery
  • Female
  • Hepatectomy
  • Humans
  • Laparoscopy
  • Length of Stay
  • Male
  • Malnutrition
  • Minimally invasive liver resections
  • NutriCatt protocol
  • Nutritional Support
  • Nutritional support
  • Oral branched-chain amino acid supplementation
  • Personalized therapy
  • Postoperative Complications
  • Recovery of Function
  • Retrospective Studies
  • Treatment Outcome


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