The impact of multidisciplinary team management on outcome of hepatic resection in liver-limited colorectal metastases

Michele Basso, S. Corallo, Maria Alessandra Calegari, Ina Valeria Zurlo, Francesco Ardito, Maria Vellone, S. Marchesani, Armando Orlandi, Vincenzo Dadduzio, G. Fuca, C. Di Dio, Caterina Mele, Brunella Barbaro, Antonia Strippoli, A. Coppola, Alessandra Cassano, Emilio Bria, Carlo Antonio Barone, Felice Giuliante

Risultato della ricerca: Contributo in rivistaArticolo in rivista

1 Citazioni (Scopus)


Hepatic resection is the gold standard treatment for patients affected by liver-limited colorectal metastases. Reports addressing the impact of multidisciplinary team (MDT) evaluation on survival are controversial. The aim of this study was to evaluate the benefit of MDT management in these patients in our Institution experience. The objective of the analysis was to compare survivals of patients managed within our MDT (MDT cohort) to those of patients referred to surgery from other hospitals without MDT discussion (non-MDT cohort). Of the 523 patients, 229 were included in the MDT cohort and 294 in the non-MDT cohort. No difference between the two groups was found in terms of median overall survival (52.5 vs 53.6 months; HR 1.13; 95% CI, 0.88–1.45; p = 0.344). In the MDT cohort there was a higher number of metastases (4.5 vs 2.7; p < 0.0001). The median duration of chemotherapy was lower in MDT patients (8 vs 10 cycles; p < 0.001). Post-operative morbidity was lower in the MDT cohort (6.2 vs 21.5%; p < 0.001). One hundred and ninety-seven patients in each group were matched by propensity score and no significant difference was observed between the two groups in terms of OS and DFS. Our study does not demonstrate a survival benefit from MDT management, but it allows surgery to patients with a more advanced disease. MDT assessment reduces the median duration of chemotherapy and post-operative morbidities.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
Numero di pagine8
RivistaScientific Reports
Stato di pubblicazionePubblicato - 2020


  • Adult
  • Aged
  • Aged, 80 and over
  • Colorectal Neoplasms
  • Colorectal Surgery
  • Disease Management
  • Female
  • Follow-Up Studies
  • Humans
  • Interdisciplinary Communication
  • Liver Neoplasms
  • Male
  • Middle Aged
  • Prognosis
  • Survival Rate
  • Young Adult


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