The Impact of COVID-19 Quarantine on Patients With Dementia and Family Caregivers: A Nation-Wide Survey

Innocenzo Rainero; Amalia C. Bruni; Camillo Marra; Annachiara Cagnin; Laura Bonanni; Chiara Cupidi; Valentina Laganà; Elisa Rubino; Alessandro Vacca; Raffaele Di Lorenzo; Paolo Provero; Valeria Isella; Nicola Vanacore; Federica Agosta; Ildebrando Appollonio; Paolo Caffarra; Cinzia Bussè; Renato Sambati; Davide Quaranta; Valeria Guglielmi; Giancarlo Logroscino; Massimo Filippi; Gioacchino Tedeschi; Carlo Ferrarese; Erica Gallo; Alberto Grassini; Andrea Marcinnò; Fausto Roveta; Paola De Martino; Francesca Frangipane; Gianfranco Puccio; Rosanna Colao; Maria Mirabelli; Chiara Terracciano; Federica Lino; Stefano Mozzetta; Gianmarco Gazzola; Giulia Camporese; Simona Sacco; Maria Carmela Lechiara; Claudia Carrarini; Mirella Russo; Alfonsina Casa Lena; Patrizia Sucapane; Pietro Tiraboschi; Paola Caroppo; Veronica Redaelli; Giuseppe Di Fede; Daniela Coppa; Lenino Peluso; Pasqualina Insarda; Matteo De Bartolo; Sabrina Esposito; Alessandro Iavarone; Carmine Fuschillo; Elena Salvatore; Chiara Criscuolo; Luisa Sambati; Rossella Santoro; Daniela Gragnaniello; Ilaria Pedriali; Livia Ludovico; Annalisa Chiari; Andrea Fabbo; Petra Bevilacqua; Chiara Galli; Silvia Magarelli; Gianfranco Spalletta; Nerisa Banaj; Giulia Caruso; Desirée Estela Porcari; Franco Giubilei; Anna Rosa Casini; Francesca Ursini; Giuseppe Bruno; Stefano Boffelli; Michela Brambilla; Giuseppe Magnani; Francesca Caso; Edoardo G. Spinelli; Elena Sinforiani; Alfredo Costa; Simona Luzzi; Gabriella Cacchiò; Marta Perini; Rossano Angeloni; Cinzia Giuli; Katia Fabi; Marco Guidi; Cristina Paci; Annaelisa Castellano; Elena Carapelle; Rossella Petrucci; Miriam Accogli; Giovanna Nicoletta Trevisi; Serena Renna; Antonella Vasquez Giuliano; Fulvio Da Re; Antonio Milia; Giuseppina Pilia; Maria Giuseppina Mascia; Valeria Putzu; Tommaso Piccoli; Luca Cuffaro; Roberto Monastero; Antonella Battaglia; Valeria Blandino; Federica Lupo; Eduardo Cumbo; Antonina Luca; Giuseppe Caravaglios; Annalisa Vezzosi; Valentina Bessi; Gloria Tognoni; Valeria Calsolaro; Giulia Lucarelli; Serena Amici; Alberto Trequattrini; Salvatore Pezzuto; Patrizia Mecocci; Giulia Caironi; Barbara Boselli; Marino Formilan; Alessandra Coin; Laura De Togni; Francesca Sala; Giulia Sandri; Maurizio Gallucci; Anna Paola Mazzarolo; Cristina Bergamelli; Serena Passoni

doi:10.3389/fnagi.2020.625781

The Impact of COVID-19 Quarantine on Patients With Dementia and Family Caregivers: A Nation-Wide Survey

Innocenzo Rainero, Amalia C. Bruni, Camillo Marra, Annachiara Cagnin, Laura Bonanni, Chiara Cupidi, Valentina Laganà, Elisa Rubino, Alessandro Vacca, Raffaele Di Lorenzo, Paolo Provero, Valeria Isella, Nicola Vanacore, Federica Agosta, Ildebrando Appollonio, Paolo Caffarra, Cinzia Bussè, Renato Sambati, Davide Quaranta, Valeria GuglielmiGiancarlo Logroscino, Massimo Filippi, Gioacchino Tedeschi, Carlo Ferrarese, Erica Gallo, Alberto Grassini, Andrea Marcinnò, Fausto Roveta, Paola De Martino, Francesca Frangipane, Gianfranco Puccio, Rosanna Colao, Maria Mirabelli, Chiara Terracciano, Federica Lino, Stefano Mozzetta, Gianmarco Gazzola, Giulia Camporese, Simona Sacco, Maria Carmela Lechiara, Claudia Carrarini, Mirella Russo, Alfonsina Casa Lena, Patrizia Sucapane, Pietro Tiraboschi, Paola Caroppo, Veronica Redaelli, Giuseppe Di Fede, Daniela Coppa, Lenino Peluso, Pasqualina Insarda, Matteo De Bartolo, Sabrina Esposito, Alessandro Iavarone, Carmine Fuschillo, Elena Salvatore, Chiara Criscuolo, Luisa Sambati, Rossella Santoro, Daniela Gragnaniello, Ilaria Pedriali, Livia Ludovico, Annalisa Chiari, Andrea Fabbo, Petra Bevilacqua, Chiara Galli, Silvia Magarelli, Gianfranco Spalletta, Nerisa Banaj, Giulia Caruso, Desirée Estela Porcari, Franco Giubilei, Anna Rosa Casini, Francesca Ursini, Giuseppe Bruno, Stefano Boffelli, Michela Brambilla, Giuseppe Magnani, Francesca Caso, Edoardo G. Spinelli, Elena Sinforiani, Alfredo Costa, Simona Luzzi, Gabriella Cacchiò, Marta Perini, Rossano Angeloni, Cinzia Giuli, Katia Fabi, Marco Guidi, Cristina Paci, Annaelisa Castellano, Elena Carapelle, Rossella Petrucci, Miriam Accogli, Giovanna Nicoletta Trevisi, Serena Renna, Antonella Vasquez Giuliano, Fulvio Da Re, Antonio Milia, Giuseppina Pilia, Maria Giuseppina Mascia, Valeria Putzu, Tommaso Piccoli, Luca Cuffaro, Roberto Monastero, Antonella Battaglia, Valeria Blandino, Federica Lupo, Eduardo Cumbo, Antonina Luca, Giuseppe Caravaglios, Annalisa Vezzosi, Valentina Bessi, Gloria Tognoni, Valeria Calsolaro, Giulia Lucarelli, Serena Amici, Alberto Trequattrini, Salvatore Pezzuto, Patrizia Mecocci, Giulia Caironi, Barbara Boselli, Marino Formilan, Alessandra Coin, Laura De Togni, Francesca Sala, Giulia Sandri, Maurizio Gallucci, Anna Paola Mazzarolo, Cristina Bergamelli, Serena Passoni

Risultato della ricerca: Contributo in rivista › Articolo in rivista

3 Citazioni (Scopus)

Abstract

Introduction: Previous studies showed that quarantine for pandemic diseases is associated with several psychological and medical effects. The consequences of quarantine for COVID-19 pandemic in patients with dementia are unknown. We investigated the clinical changes in patients with Alzheimer’s disease and other dementias, and evaluated caregivers’ distress during COVID-19 quarantine. Methods: The study involved 87 Italian Dementia Centers. Patients with Alzheimer’s Disease (AD), Dementia with Lewy Bodies (DLB), Frontotemporal Dementia (FTD), and Vascular Dementia (VD) were eligible for the study. Family caregivers of patients with dementia were interviewed by phone in April 2020, 45 days after quarantine declaration. Main outcomes were patients’ changes in cognitive, behavioral, and motor symptoms. Secondary outcomes were effects on caregivers’ psychological features. Results: 4913 patients (2934 females, 1979 males) fulfilled the inclusion criteria. Caregivers reported a worsening in cognitive functions in 55.1% of patients, mainly in subjects with DLB and AD. Aggravation of behavioral symptoms was observed in 51.9% of patients. In logistic regression analysis, previous physical independence was associated with both cognitive and behavioral worsening (odds ratio 1.85 [95% CI 1.42–2.39], 1.84 [95% CI 1.43–2.38], respectively). On the contrary, pandemic awareness was a protective factor for the worsening of cognitive and behavioral symptoms (odds ratio 0.74 [95% CI 0.65–0.85]; and 0.72 [95% CI 0.63–0.82], respectively). Approximately 25.9% of patients showed the onset of new behavioral symptoms. A worsening in motor function was reported by 36.7% of patients. Finally, caregivers reported a high increase in anxiety, depression, and distress. Conclusion: Our study shows that quarantine for COVID-19 is associated with an acute worsening of clinical symptoms in patients with dementia as well as increase of caregivers’ burden. Our findings emphasize the importance to implement new strategies to mitigate the effects of quarantine in patients with dementia.

Lingua originale	English
pagine (da-a)	N/A-N/A
Numero di pagine	12
Rivista	Frontiers in Aging Neuroscience
Volume	12
DOI	https://doi.org/10.3389/fnagi.2020.625781
Stato di pubblicazione	Pubblicato - 2021

Keywords

Alzheimer’s disease
BPSD
COVID-19
caregiver burden
dementia
quarantine

Accesso al documento

10.3389/fnagi.2020.625781

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Rainero, I., Bruni, A. C., Marra, C., Cagnin, A., Bonanni, L., Cupidi, C., Laganà, V., Rubino, E., Vacca, A., Lorenzo, R. D., Provero, P., Isella, V., Vanacore, N., Agosta, F., Appollonio, I., Caffarra, P., Bussè, C., Sambati, R., Quaranta, D., ... Passoni, S. (2021). The Impact of COVID-19 Quarantine on Patients With Dementia and Family Caregivers: A Nation-Wide Survey. Frontiers in Aging Neuroscience, 12, N/A-N/A. https://doi.org/10.3389/fnagi.2020.625781

@article{22ecf1130c0a491ba64d69f912e734cf,

title = "The Impact of COVID-19 Quarantine on Patients With Dementia and Family Caregivers: A Nation-Wide Survey",

abstract = "Introduction: Previous studies showed that quarantine for pandemic diseases is associated with several psychological and medical effects. The consequences of quarantine for COVID-19 pandemic in patients with dementia are unknown. We investigated the clinical changes in patients with Alzheimer{\textquoteright}s disease and other dementias, and evaluated caregivers{\textquoteright} distress during COVID-19 quarantine. Methods: The study involved 87 Italian Dementia Centers. Patients with Alzheimer{\textquoteright}s Disease (AD), Dementia with Lewy Bodies (DLB), Frontotemporal Dementia (FTD), and Vascular Dementia (VD) were eligible for the study. Family caregivers of patients with dementia were interviewed by phone in April 2020, 45 days after quarantine declaration. Main outcomes were patients{\textquoteright} changes in cognitive, behavioral, and motor symptoms. Secondary outcomes were effects on caregivers{\textquoteright} psychological features. Results: 4913 patients (2934 females, 1979 males) fulfilled the inclusion criteria. Caregivers reported a worsening in cognitive functions in 55.1% of patients, mainly in subjects with DLB and AD. Aggravation of behavioral symptoms was observed in 51.9% of patients. In logistic regression analysis, previous physical independence was associated with both cognitive and behavioral worsening (odds ratio 1.85 [95% CI 1.42–2.39], 1.84 [95% CI 1.43–2.38], respectively). On the contrary, pandemic awareness was a protective factor for the worsening of cognitive and behavioral symptoms (odds ratio 0.74 [95% CI 0.65–0.85]; and 0.72 [95% CI 0.63–0.82], respectively). Approximately 25.9% of patients showed the onset of new behavioral symptoms. A worsening in motor function was reported by 36.7% of patients. Finally, caregivers reported a high increase in anxiety, depression, and distress. Conclusion: Our study shows that quarantine for COVID-19 is associated with an acute worsening of clinical symptoms in patients with dementia as well as increase of caregivers{\textquoteright} burden. Our findings emphasize the importance to implement new strategies to mitigate the effects of quarantine in patients with dementia.",

keywords = "Alzheimer{\textquoteright}s disease, BPSD, COVID-19, caregiver burden, dementia, quarantine, Alzheimer{\textquoteright}s disease, BPSD, COVID-19, caregiver burden, dementia, quarantine",

author = "Innocenzo Rainero and Bruni, {Amalia C.} and Camillo Marra and Annachiara Cagnin and Laura Bonanni and Chiara Cupidi and Valentina Lagan{\`a} and Elisa Rubino and Alessandro Vacca and Lorenzo, {Raffaele Di} and Paolo Provero and Valeria Isella and Nicola Vanacore and Federica Agosta and Ildebrando Appollonio and Paolo Caffarra and Cinzia Buss{\`e} and Renato Sambati and Davide Quaranta and Valeria Guglielmi and Giancarlo Logroscino and Massimo Filippi and Gioacchino Tedeschi and Carlo Ferrarese and Erica Gallo and Alberto Grassini and Andrea Marcinn{\`o} and Fausto Roveta and {De Martino}, Paola and Francesca Frangipane and Gianfranco Puccio and Rosanna Colao and Maria Mirabelli and Chiara Terracciano and Federica Lino and Stefano Mozzetta and Gianmarco Gazzola and Giulia Camporese and Simona Sacco and Lechiara, {Maria Carmela} and Claudia Carrarini and Mirella Russo and {Casa Lena}, Alfonsina and Patrizia Sucapane and Pietro Tiraboschi and Paola Caroppo and Veronica Redaelli and {Di Fede}, Giuseppe and Daniela Coppa and Lenino Peluso and Pasqualina Insarda and {De Bartolo}, Matteo and Sabrina Esposito and Alessandro Iavarone and Carmine Fuschillo and Elena Salvatore and Chiara Criscuolo and Luisa Sambati and Rossella Santoro and Daniela Gragnaniello and Ilaria Pedriali and Livia Ludovico and Annalisa Chiari and Andrea Fabbo and Petra Bevilacqua and Chiara Galli and Silvia Magarelli and Gianfranco Spalletta and Nerisa Banaj and Giulia Caruso and {Estela Porcari}, Desir{\'e}e and Franco Giubilei and Casini, {Anna Rosa} and Francesca Ursini and Giuseppe Bruno and Stefano Boffelli and Michela Brambilla and Giuseppe Magnani and Francesca Caso and Spinelli, {Edoardo G.} and Elena Sinforiani and Alfredo Costa and Simona Luzzi and Gabriella Cacchi{\`o} and Marta Perini and Rossano Angeloni and Cinzia Giuli and Katia Fabi and Marco Guidi and Cristina Paci and Annaelisa Castellano and Elena Carapelle and Rossella Petrucci and Miriam Accogli and {Nicoletta Trevisi}, Giovanna and Serena Renna and Giuliano, {Antonella Vasquez} and {Da Re}, Fulvio and Antonio Milia and Giuseppina Pilia and Mascia, {Maria Giuseppina} and Valeria Putzu and Tommaso Piccoli and Luca Cuffaro and Roberto Monastero and Antonella Battaglia and Valeria Blandino and Federica Lupo and Eduardo Cumbo and Antonina Luca and Giuseppe Caravaglios and Annalisa Vezzosi and Valentina Bessi and Gloria Tognoni and Valeria Calsolaro and Giulia Lucarelli and Serena Amici and Alberto Trequattrini and Salvatore Pezzuto and Patrizia Mecocci and Giulia Caironi and Barbara Boselli and Marino Formilan and Alessandra Coin and {De Togni}, Laura and Francesca Sala and Giulia Sandri and Maurizio Gallucci and Mazzarolo, {Anna Paola} and Cristina Bergamelli and Serena Passoni",

year = "2021",

doi = "10.3389/fnagi.2020.625781",

language = "English",

volume = "12",

pages = "N/A--N/A",

journal = "Frontiers in Aging Neuroscience",

issn = "1663-4365",

publisher = "Frontiers Media SA",

}

Rainero, I, Bruni, AC, Marra, C, Cagnin, A, Bonanni, L, Cupidi, C, Laganà, V, Rubino, E, Vacca, A, Lorenzo, RD, Provero, P, Isella, V, Vanacore, N, Agosta, F, Appollonio, I, Caffarra, P, Bussè, C, Sambati, R, Quaranta, D, Guglielmi, V, Logroscino, G, Filippi, M, Tedeschi, G, Ferrarese, C, Gallo, E, Grassini, A, Marcinnò, A, Roveta, F, De Martino, P, Frangipane, F, Puccio, G, Colao, R, Mirabelli, M, Terracciano, C, Lino, F, Mozzetta, S, Gazzola, G, Camporese, G, Sacco, S, Lechiara, MC, Carrarini, C, Russo, M, Casa Lena, A, Sucapane, P, Tiraboschi, P, Caroppo, P, Redaelli, V, Di Fede, G, Coppa, D, Peluso, L, Insarda, P, De Bartolo, M, Esposito, S, Iavarone, A, Fuschillo, C, Salvatore, E, Criscuolo, C, Sambati, L, Santoro, R, Gragnaniello, D, Pedriali, I, Ludovico, L, Chiari, A, Fabbo, A, Bevilacqua, P, Galli, C, Magarelli, S, Spalletta, G, Banaj, N, Caruso, G, Estela Porcari, D, Giubilei, F, Casini, AR, Ursini, F, Bruno, G, Boffelli, S, Brambilla, M, Magnani, G, Caso, F, Spinelli, EG, Sinforiani, E, Costa, A, Luzzi, S, Cacchiò, G, Perini, M, Angeloni, R, Giuli, C, Fabi, K, Guidi, M, Paci, C, Castellano, A, Carapelle, E, Petrucci, R, Accogli, M, Nicoletta Trevisi, G, Renna, S, Giuliano, AV, Da Re, F, Milia, A, Pilia, G, Mascia, MG, Putzu, V, Piccoli, T, Cuffaro, L, Monastero, R, Battaglia, A, Blandino, V, Lupo, F, Cumbo, E, Luca, A, Caravaglios, G, Vezzosi, A, Bessi, V, Tognoni, G, Calsolaro, V, Lucarelli, G, Amici, S, Trequattrini, A, Pezzuto, S, Mecocci, P, Caironi, G, Boselli, B, Formilan, M, Coin, A, De Togni, L, Sala, F, Sandri, G, Gallucci, M, Mazzarolo, AP, Bergamelli, C & Passoni, S 2021, 'The Impact of COVID-19 Quarantine on Patients With Dementia and Family Caregivers: A Nation-Wide Survey', Frontiers in Aging Neuroscience, vol. 12, pagg. N/A-N/A. https://doi.org/10.3389/fnagi.2020.625781

TY - JOUR

T1 - The Impact of COVID-19 Quarantine on Patients With Dementia and Family Caregivers: A Nation-Wide Survey

AU - Rainero, Innocenzo

AU - Bruni, Amalia C.

AU - Marra, Camillo

AU - Cagnin, Annachiara

AU - Bonanni, Laura

AU - Cupidi, Chiara

AU - Laganà, Valentina

AU - Rubino, Elisa

AU - Vacca, Alessandro

AU - Lorenzo, Raffaele Di

AU - Provero, Paolo

AU - Isella, Valeria

AU - Vanacore, Nicola

AU - Agosta, Federica

AU - Appollonio, Ildebrando

AU - Caffarra, Paolo

AU - Bussè, Cinzia

AU - Sambati, Renato

AU - Quaranta, Davide

AU - Guglielmi, Valeria

AU - Logroscino, Giancarlo

AU - Filippi, Massimo

AU - Tedeschi, Gioacchino

AU - Ferrarese, Carlo

AU - Gallo, Erica

AU - Grassini, Alberto

AU - Marcinnò, Andrea

AU - Roveta, Fausto

AU - De Martino, Paola

AU - Frangipane, Francesca

AU - Puccio, Gianfranco

AU - Colao, Rosanna

AU - Mirabelli, Maria

AU - Terracciano, Chiara

AU - Lino, Federica

AU - Mozzetta, Stefano

AU - Gazzola, Gianmarco

AU - Camporese, Giulia

AU - Sacco, Simona

AU - Lechiara, Maria Carmela

AU - Carrarini, Claudia

AU - Russo, Mirella

AU - Casa Lena, Alfonsina

AU - Sucapane, Patrizia

AU - Tiraboschi, Pietro

AU - Caroppo, Paola

AU - Redaelli, Veronica

AU - Di Fede, Giuseppe

AU - Coppa, Daniela

AU - Peluso, Lenino

AU - Insarda, Pasqualina

AU - De Bartolo, Matteo

AU - Esposito, Sabrina

AU - Iavarone, Alessandro

AU - Fuschillo, Carmine

AU - Salvatore, Elena

AU - Criscuolo, Chiara

AU - Sambati, Luisa

AU - Santoro, Rossella

AU - Gragnaniello, Daniela

AU - Pedriali, Ilaria

AU - Ludovico, Livia

AU - Chiari, Annalisa

AU - Fabbo, Andrea

AU - Bevilacqua, Petra

AU - Galli, Chiara

AU - Magarelli, Silvia

AU - Spalletta, Gianfranco

AU - Banaj, Nerisa

AU - Caruso, Giulia

AU - Estela Porcari, Desirée

AU - Giubilei, Franco

AU - Casini, Anna Rosa

AU - Ursini, Francesca

AU - Bruno, Giuseppe

AU - Boffelli, Stefano

AU - Brambilla, Michela

AU - Magnani, Giuseppe

AU - Caso, Francesca

AU - Spinelli, Edoardo G.

AU - Sinforiani, Elena

AU - Costa, Alfredo

AU - Luzzi, Simona

AU - Cacchiò, Gabriella

AU - Perini, Marta

AU - Angeloni, Rossano

AU - Giuli, Cinzia

AU - Fabi, Katia

AU - Guidi, Marco

AU - Paci, Cristina

AU - Castellano, Annaelisa

AU - Carapelle, Elena

AU - Petrucci, Rossella

AU - Accogli, Miriam

AU - Nicoletta Trevisi, Giovanna

AU - Renna, Serena

AU - Giuliano, Antonella Vasquez

AU - Da Re, Fulvio

AU - Milia, Antonio

AU - Pilia, Giuseppina

AU - Mascia, Maria Giuseppina

AU - Putzu, Valeria

AU - Piccoli, Tommaso

AU - Cuffaro, Luca

AU - Monastero, Roberto

AU - Battaglia, Antonella

AU - Blandino, Valeria

AU - Lupo, Federica

AU - Cumbo, Eduardo

AU - Luca, Antonina

AU - Caravaglios, Giuseppe

AU - Vezzosi, Annalisa

AU - Bessi, Valentina

AU - Tognoni, Gloria

AU - Calsolaro, Valeria

AU - Lucarelli, Giulia

AU - Amici, Serena

AU - Trequattrini, Alberto

AU - Pezzuto, Salvatore

AU - Mecocci, Patrizia

AU - Caironi, Giulia

AU - Boselli, Barbara

AU - Formilan, Marino

AU - Coin, Alessandra

AU - De Togni, Laura

AU - Sala, Francesca

AU - Sandri, Giulia

AU - Gallucci, Maurizio

AU - Mazzarolo, Anna Paola

AU - Bergamelli, Cristina

AU - Passoni, Serena

PY - 2021

Y1 - 2021

N2 - Introduction: Previous studies showed that quarantine for pandemic diseases is associated with several psychological and medical effects. The consequences of quarantine for COVID-19 pandemic in patients with dementia are unknown. We investigated the clinical changes in patients with Alzheimer’s disease and other dementias, and evaluated caregivers’ distress during COVID-19 quarantine. Methods: The study involved 87 Italian Dementia Centers. Patients with Alzheimer’s Disease (AD), Dementia with Lewy Bodies (DLB), Frontotemporal Dementia (FTD), and Vascular Dementia (VD) were eligible for the study. Family caregivers of patients with dementia were interviewed by phone in April 2020, 45 days after quarantine declaration. Main outcomes were patients’ changes in cognitive, behavioral, and motor symptoms. Secondary outcomes were effects on caregivers’ psychological features. Results: 4913 patients (2934 females, 1979 males) fulfilled the inclusion criteria. Caregivers reported a worsening in cognitive functions in 55.1% of patients, mainly in subjects with DLB and AD. Aggravation of behavioral symptoms was observed in 51.9% of patients. In logistic regression analysis, previous physical independence was associated with both cognitive and behavioral worsening (odds ratio 1.85 [95% CI 1.42–2.39], 1.84 [95% CI 1.43–2.38], respectively). On the contrary, pandemic awareness was a protective factor for the worsening of cognitive and behavioral symptoms (odds ratio 0.74 [95% CI 0.65–0.85]; and 0.72 [95% CI 0.63–0.82], respectively). Approximately 25.9% of patients showed the onset of new behavioral symptoms. A worsening in motor function was reported by 36.7% of patients. Finally, caregivers reported a high increase in anxiety, depression, and distress. Conclusion: Our study shows that quarantine for COVID-19 is associated with an acute worsening of clinical symptoms in patients with dementia as well as increase of caregivers’ burden. Our findings emphasize the importance to implement new strategies to mitigate the effects of quarantine in patients with dementia.

AB - Introduction: Previous studies showed that quarantine for pandemic diseases is associated with several psychological and medical effects. The consequences of quarantine for COVID-19 pandemic in patients with dementia are unknown. We investigated the clinical changes in patients with Alzheimer’s disease and other dementias, and evaluated caregivers’ distress during COVID-19 quarantine. Methods: The study involved 87 Italian Dementia Centers. Patients with Alzheimer’s Disease (AD), Dementia with Lewy Bodies (DLB), Frontotemporal Dementia (FTD), and Vascular Dementia (VD) were eligible for the study. Family caregivers of patients with dementia were interviewed by phone in April 2020, 45 days after quarantine declaration. Main outcomes were patients’ changes in cognitive, behavioral, and motor symptoms. Secondary outcomes were effects on caregivers’ psychological features. Results: 4913 patients (2934 females, 1979 males) fulfilled the inclusion criteria. Caregivers reported a worsening in cognitive functions in 55.1% of patients, mainly in subjects with DLB and AD. Aggravation of behavioral symptoms was observed in 51.9% of patients. In logistic regression analysis, previous physical independence was associated with both cognitive and behavioral worsening (odds ratio 1.85 [95% CI 1.42–2.39], 1.84 [95% CI 1.43–2.38], respectively). On the contrary, pandemic awareness was a protective factor for the worsening of cognitive and behavioral symptoms (odds ratio 0.74 [95% CI 0.65–0.85]; and 0.72 [95% CI 0.63–0.82], respectively). Approximately 25.9% of patients showed the onset of new behavioral symptoms. A worsening in motor function was reported by 36.7% of patients. Finally, caregivers reported a high increase in anxiety, depression, and distress. Conclusion: Our study shows that quarantine for COVID-19 is associated with an acute worsening of clinical symptoms in patients with dementia as well as increase of caregivers’ burden. Our findings emphasize the importance to implement new strategies to mitigate the effects of quarantine in patients with dementia.

KW - Alzheimer’s disease

KW - BPSD

KW - COVID-19

KW - caregiver burden

KW - dementia

KW - quarantine

KW - Alzheimer’s disease

KW - BPSD

KW - COVID-19

KW - caregiver burden

KW - dementia

KW - quarantine

UR - http://hdl.handle.net/10807/179158

U2 - 10.3389/fnagi.2020.625781

DO - 10.3389/fnagi.2020.625781

M3 - Article

SN - 1663-4365

VL - 12

SP - N/A-N/A

JO - Frontiers in Aging Neuroscience

JF - Frontiers in Aging Neuroscience

ER -

The Impact of COVID-19 Quarantine on Patients With Dementia and Family Caregivers: A Nation-Wide Survey

Abstract

Keywords

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