The Impact of Cognitive Reserve on Brain Functional Connectivity in Alzheimer's Disease

Marco Bozzali, Claire Dowling, Laura Serra, Barbara Spanó, Mario Torso, Camillo Marra, Daniela Castelli, Nicholas G. Dowell, Giacomo Koch, Carlo Caltagirone, Mara Cercignani

Risultato della ricerca: Contributo in rivistaArticolo in rivista

65 Citazioni (Scopus)


One factor believed to impact brain resilience to the pathological damage of Alzheimer's disease (AD) is the so-called "cognitive reserve" (CR). A critical issue that still needs to be fully understood is the mechanism by which environmental enrichment interacts with brain plasticity to determine resilience to AD pathology. Previous work using PET suggests that increased brain connectivity might be at the origin of the compensatory mechanisms implicated in this process. This study aims to further clarify this issue using resting-state functional MRI. Resting-state functional MRI was collected for 11 patients with AD, 18 with mild cognitive impairment (MCI), and 16 healthy controls, and analyzed to isolate the default mode network (DMN). A quantitative score of CR was obtained by combining information about number of years of education and type of schools attended. Consistent with previous reports, education was found to modulate functional connectivity in the posterior cingulate cortex, whose disconnection with the temporal lobes is known to be critical for the conversion from MCI to AD. This effect was highly significant in AD patients, less so in patients with MCI, and absent in healthy subjects. These findings show the potential neural mechanisms underlying the individual's ability to cope with brain damage, although they should be treated with some caution based on small numbers.
Lingua originaleEnglish
pagine (da-a)243-250
Numero di pagine8
RivistaJournal of Alzheimer's Disease
Stato di pubblicazionePubblicato - 2015


  • Alzheimer's disease
  • cognitive reserve
  • mild cognitive impairment
  • resting-state functional MRI


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