The Immunologic Role of IL-17 in Psoriasis and Psoriatic Arthritis Pathogenesis

Andrea Chiricozzi, Andrew Blauvelt

Risultato della ricerca: Contributo in rivistaArticolo in rivista

131 Citazioni (Scopus)

Abstract

Psoriasis is a chronic, immune-mediated, inflammatory disease that is pathogenically driven by proinflammatory cytokines. This article reviews the immunologic role of interleukin (IL)-17, the major effector cytokine in the pathogenesis of psoriatic disease, along with the rationale for targeting the IL-17 cytokine family (IL-17A, IL-17F, and IL-17 receptor A) in the treatment of psoriasis and psoriatic arthritis. Emerging evidence indicates that major sources of IL-17A in patients with psoriatic disease are mast cells, γδ T cells, αβ T cells, and innate lymphoid cells in lesional skin and synovial fluid. Within the skin and joints, IL-17A acts on cellular targets, including keratinocytes, neutrophils, endothelial cells, fibroblasts, osteoclasts, chondrocytes, and osteoblasts, to stimulate production of various antimicrobial peptides, chemokines, and proinflammatory and proliferative cytokines, which, in turn, promote tissue inflammation and bone remodeling. The critical importance of the IL-23/IL-17A axis to the pathogenesis of psoriatic disease has resulted in many new biologic treatments targeting these cytokines. These biologics dramatically improve skin and joint symptoms in patients with moderate-to-severe psoriasis and psoriatic arthritis.
Lingua originaleEnglish
pagine (da-a)379-390
Numero di pagine12
RivistaCLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
Volume55
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • Adaptive Immunity
  • Adaptive immunity
  • Arthritis, Psoriatic
  • Cytokines
  • Disease Susceptibility
  • Humans
  • IL-17 receptor A
  • IL-17A
  • IL-17F
  • Immunity, Innate
  • Inflammation Mediators
  • Innate immunity
  • Interleukin-17
  • Psoriasis
  • Receptors, Interleukin-17
  • Th17 Cells

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