TY - JOUR
T1 - The immune microenviroment in somatotropinomas: from biology to personalized and target therapy
AU - Chiloiro, Sabrina
AU - De Marinis Grasso, Laura
PY - 2023
Y1 - 2023
N2 - Pituitary tumors are rare neoplasms, with a heterogeneous biological and clinical behavior, due to their clinical course, local invasive growth, resistance to conventional therapies and the risk of disease progression. Recent studies on tumor microenvironment (TME) provided new knowledge on the biology of these neoplasia, that may explain the different phenotypes of these tumors and suggest new biomarkers able to predict the prognosis and the treatment outcome. The identification of molecular markers that act as targets for biological therapies may open new perspectives in the medical treatments of aggressive pituitary tumors.In this paper, we will review data of TME and target therapies in somatotropinomas.
AB - Pituitary tumors are rare neoplasms, with a heterogeneous biological and clinical behavior, due to their clinical course, local invasive growth, resistance to conventional therapies and the risk of disease progression. Recent studies on tumor microenvironment (TME) provided new knowledge on the biology of these neoplasia, that may explain the different phenotypes of these tumors and suggest new biomarkers able to predict the prognosis and the treatment outcome. The identification of molecular markers that act as targets for biological therapies may open new perspectives in the medical treatments of aggressive pituitary tumors.In this paper, we will review data of TME and target therapies in somatotropinomas.
KW - acromegaly
KW - acromegaly
UR - http://hdl.handle.net/10807/230208
U2 - 10.1007/s11154-022-09782-1
DO - 10.1007/s11154-022-09782-1
M3 - Article
SN - 1389-9155
VL - 24
SP - 283
EP - 295
JO - Reviews in Endocrine and Metabolic Disorders
JF - Reviews in Endocrine and Metabolic Disorders
ER -