The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain

Luca Tamagnone, J. Partanen, E. Armstrong, J. Lasota, K. Ohgami, T. Tazunoki, S. Laforgia, K. Huebner, K. Alitalo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

27 Citazioni (Scopus)

Abstract

The human ryk tyrosine kinase cDNA was originally identified as a PCR-amplified cDNA fragment (JTK5) from K562 leukemia cells and found to represent a ubiquitously expressed gene (Partanen et al., 1990). The open reading frame of human ryk, reported here, encodes a novel type of putative tyrosine kinase of 607 amino acid residues, having two potential transmembrane domains and homology to receptor tyrosine kinases, such as met (HGF/SF-R) and IGF-1R, in its catalytic domain. The gene maps to human chromosome 3q11-25. Expression of the 3.4 kb ryk mRNA was found in all human adult tissues examined.
Lingua originaleEnglish
pagine (da-a)2009-2014
Numero di pagine6
RivistaOncogene
Volume8
Stato di pubblicazionePubblicato - 1993

Keywords

  • Cancer Research
  • Genetics
  • Molecular Biology

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