TY - JOUR
T1 - The human leucocyte antigen-G 14-basepair polymorphism correlates with graft-versus-host disease in unrelated bone marrow transplantation for thalassaemia
AU - La Nasa, Giorgio
AU - Littera, Roberto
AU - Locatelli, Franco
AU - Lai, Sara
AU - Alba, Francesco
AU - Caocci, Giovanni
AU - Lisini, Daniela
AU - Nesci, Sonia
AU - Vacca, Adriana
AU - Piras, Eugenia
AU - Bernardo, Maria Ester
AU - Cesare-Merlone, Alessandra Di
AU - Orrù, Sandro
AU - Carcassi, Carlo
PY - 2007
Y1 - 2007
N2 - The presence of the 14-bp insertion polymorphism of the human leucocyte antigen (HLA)-G gene (HLA-G) promotes immune tolerance through increased synthesis of HLA-G molecules. We investigated this polymorphism in a large cohort of 53 thalassaemia patients transplanted from an unrelated donor. Sixteen patients (30.2%) homozygous for the 14-bp deletion had a higher risk of developing acute graft-versus-host disease (aGvHD) than patients homozygous for the 14-bp insertion (-14-bp/-14-bp vs +14-bp/+14-bp: Relative Risk = 15.0; 95% confidence interval 1.59-141.24; P = 0.008). Therefore, the 14-bp polymorphism could be an important predictive factor for aGvHD following bone marrow transplantation.
AB - The presence of the 14-bp insertion polymorphism of the human leucocyte antigen (HLA)-G gene (HLA-G) promotes immune tolerance through increased synthesis of HLA-G molecules. We investigated this polymorphism in a large cohort of 53 thalassaemia patients transplanted from an unrelated donor. Sixteen patients (30.2%) homozygous for the 14-bp deletion had a higher risk of developing acute graft-versus-host disease (aGvHD) than patients homozygous for the 14-bp insertion (-14-bp/-14-bp vs +14-bp/+14-bp: Relative Risk = 15.0; 95% confidence interval 1.59-141.24; P = 0.008). Therefore, the 14-bp polymorphism could be an important predictive factor for aGvHD following bone marrow transplantation.
KW - human leucocyte antigen-G
KW - 14-basepair polymorphism
KW - bone marrow transplantation
KW - thalassaemia
KW - acute graft-versus-host disease
KW - human leucocyte antigen-G
KW - 14-basepair polymorphism
KW - bone marrow transplantation
KW - thalassaemia
KW - acute graft-versus-host disease
UR - http://hdl.handle.net/10807/257386
U2 - 10.1111/j.1365-2141.2007.06779.x
DO - 10.1111/j.1365-2141.2007.06779.x
M3 - Article
SN - 0007-1048
VL - 139
SP - 284
EP - 288
JO - British Journal of Haematology
JF - British Journal of Haematology
ER -
