The Hippo transducers TAZ and YAP in breast cancer: Oncogenic activities and clinical implications

Ruggero De Maria Marchiano, Ilio Vitale, Marcello Maugeri-Saccà, Maddalena Barba, Laura Pizzuti, Patrizia Vici, Luigi Di Lauro, Rosanna Dattilo, Monica Bartucci, Marcella Mottolese

Risultato della ricerca: Contributo in rivistaArticolo in rivista

43 Citazioni (Scopus)

Abstract

The Hippo signalling is emerging as a tumour suppressor pathway whose function is regulated by an intricate network of intracellular and extracellular cues. Defects in the signal cascade lead to the activation of the Hippo transducers TAZ and YAP. Compelling preclinical evidence showed that TAZ/YAP are often aberrantly engaged in breast cancer (BC), where their hyperactivation culminates into a variety of tumour-promoting functions such as epithelial-to-mesenchymal transition, cancer stem cell generation and therapeutic resistance. Having acquired a more thorough understanding in the biology of TAZ/YAP, and the molecular outputs they elicit, has prompted a first wave of exploratory, clinically-focused analyses aimed at providing initial hints on the prognostic/predictive significance of their expression. In this review, we discuss oncogenic activities linked with TAZ/YAP in BC, and we propose clinical strategies for investigating their role as biomarkers in the clinical setting. Finally, we address the therapeutic potential of TAZ/YAP targeting and the modalities that, in our opinion, should be pursued in order to further study the biological and clinical consequences of their inhibition.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaExpert Reviews in Molecular Medicine
Volume17
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • Adaptor Proteins, Signal Transducing
  • Antineoplastic Agents
  • Breast Neoplasms
  • Clinical Trials as Topic
  • Drug Resistance, Neoplasm
  • Epithelial-Mesenchymal Transition
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Intracellular Signaling Peptides and Proteins
  • Molecular Biology
  • Molecular Medicine
  • Neoplastic Stem Cells
  • Phosphoproteins
  • Phosphorylation
  • Signal Transduction

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