The hedgehog signaling pathway in ischemic tissues

Igor Giarretta, Eleonora Gaetani, Margherita Bigossi, Paolo Tondi, Takayuki Asahara, Roberto Pola*

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

2 Citazioni (Scopus)


Hedgehog (Hh) proteins are prototypical morphogens known to regulate epithelial/mesenchymal interactions during embryonic development. In addition to its pivotal role in embryogenesis, the Hh signaling pathway may be recapitulated in post-natal life in a number of physiological and pathological conditions, including ischemia. This review highlights the involvement of Hh signaling in ischemic tissue regeneration and angiogenesis, with particular attention to the heart, the brain, and the skeletal muscle. Updated information on the potential role of the Hh pathway as a therapeutic target in the ischemic condition is also presented.
Lingua originaleEnglish
pagine (da-a)5270-N/A
RivistaInternational Journal of Molecular Sciences
Stato di pubblicazionePubblicato - 2019


  • Animals
  • Brain
  • Heart
  • Hedgehog
  • Hedgehog Proteins
  • Humans
  • Ischemia
  • Muscle, Skeletal
  • Myocardium
  • Signal Transduction
  • Skeletal muscle


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