The hbhA gene of Mycobacterium tuberculosis is specifically upregulated in the lungs but not in the spleens of aerogenically infected mice

Giovanni Delogu; Maurizio Sanguinetti; Brunella Posteraro; S Rocca; S Zanetti; Giovanni Fadda

doi:10.1128/IAI.74.5.3006-3011.2006

The hbhA gene of Mycobacterium tuberculosis is specifically upregulated in the lungs but not in the spleens of aerogenically infected mice

Giovanni Delogu, Maurizio Sanguinetti, Brunella Posteraro, S Rocca, S Zanetti, Giovanni Fadda

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

28 Citazioni (Scopus)

Abstract

We report that hbhA is differentially regulated during Mycobacterium tuberculosis infection. Upregulation was observed in epithelial cell infection but not in macrophage infection and in the lungs but not in the spleens of infected mice, and it was greater during the early steps of infection, when bacilli disseminate from the site of primary infection.

Lingua originale	English
pagine (da-a)	3006-3011
Numero di pagine	6
Rivista	Infection and Immunity
Volume	74
DOI	https://doi.org/10.1128/IAI.74.5.3006-3011.2006
Stato di pubblicazione	Pubblicato - 2006

Keywords

Animals
Bacterial Proteins
Cytoskeletal Proteins
Female
Gene Expression Regulation, Bacterial
Lung
Membrane Proteins
Mice
Mice, Inbred C57BL
Organ Specificity
Recombinant Proteins
Spleen
Up-Regulation

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title = "The hbhA gene of Mycobacterium tuberculosis is specifically upregulated in the lungs but not in the spleens of aerogenically infected mice",

abstract = "We report that hbhA is differentially regulated during Mycobacterium tuberculosis infection. Upregulation was observed in epithelial cell infection but not in macrophage infection and in the lungs but not in the spleens of infected mice, and it was greater during the early steps of infection, when bacilli disseminate from the site of primary infection.",

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author = "Giovanni Delogu and Maurizio Sanguinetti and Brunella Posteraro and S Rocca and S Zanetti and Giovanni Fadda",

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doi = "10.1128/IAI.74.5.3006-3011.2006",

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TY - JOUR

T1 - The hbhA gene of Mycobacterium tuberculosis is specifically upregulated in the lungs but not in the spleens of aerogenically infected mice

AU - Delogu, Giovanni

AU - Sanguinetti, Maurizio

AU - Posteraro, Brunella

AU - Rocca, S

AU - Zanetti, S

AU - Fadda, Giovanni

PY - 2006

Y1 - 2006

N2 - We report that hbhA is differentially regulated during Mycobacterium tuberculosis infection. Upregulation was observed in epithelial cell infection but not in macrophage infection and in the lungs but not in the spleens of infected mice, and it was greater during the early steps of infection, when bacilli disseminate from the site of primary infection.

AB - We report that hbhA is differentially regulated during Mycobacterium tuberculosis infection. Upregulation was observed in epithelial cell infection but not in macrophage infection and in the lungs but not in the spleens of infected mice, and it was greater during the early steps of infection, when bacilli disseminate from the site of primary infection.

KW - Animals

KW - Bacterial Proteins

KW - Cytoskeletal Proteins

KW - Female

KW - Gene Expression Regulation, Bacterial

KW - Lung

KW - Membrane Proteins

KW - Mice

KW - Mice, Inbred C57BL

KW - Organ Specificity

KW - Recombinant Proteins

KW - Spleen

KW - Up-Regulation

KW - Animals

KW - Bacterial Proteins

KW - Cytoskeletal Proteins

KW - Female

KW - Gene Expression Regulation, Bacterial

KW - Lung

KW - Membrane Proteins

KW - Mice

KW - Mice, Inbred C57BL

KW - Organ Specificity

KW - Recombinant Proteins

KW - Spleen

KW - Up-Regulation

UR - http://hdl.handle.net/10807/6596

U2 - 10.1128/IAI.74.5.3006-3011.2006

DO - 10.1128/IAI.74.5.3006-3011.2006

M3 - Article

SN - 0019-9567

VL - 74

SP - 3006

EP - 3011

JO - Infection and Immunity

JF - Infection and Immunity

ER -

The hbhA gene of Mycobacterium tuberculosis is specifically upregulated in the lungs but not in the spleens of aerogenically infected mice

Abstract

Keywords

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