TY - JOUR
T1 - THE GUT MICROBIOTA AND IMMUNE SYSTEM RELATIONSHIP IN HUMAN GRAFT-VERSUS-HOST DISEASE
AU - Laterza, Lucrezia
AU - Rizzatti, Gianenrico
AU - Gaetani, Eleonora
AU - Chiusolo, Patrizia
AU - Gasbarrini, Antonio
PY - 2016
Y1 - 2016
N2 - of Gut microbiota has gained increasing interest in the pathogenesis immune-related diseases. In this context, graft-versus-host disease is a condition characterized by an immune response which frequently complicates and limits the outcomes of hematopoietic stem cell transplantations. Past studies, carried mostly in animals, already supported a relationship between gut microbiota and graft-versus-host disease. However, the possible mechanisms underlying this connection remain elusory. Moreover, strategies to prevent graft-versus-host disease are of great interest as well as the potential role of gut microbiota modulation. We reviewed the role of gut microbiota in the development of immune system and its involvement in the graft-versus-host disease, focusing on data available on humans.
AB - of Gut microbiota has gained increasing interest in the pathogenesis immune-related diseases. In this context, graft-versus-host disease is a condition characterized by an immune response which frequently complicates and limits the outcomes of hematopoietic stem cell transplantations. Past studies, carried mostly in animals, already supported a relationship between gut microbiota and graft-versus-host disease. However, the possible mechanisms underlying this connection remain elusory. Moreover, strategies to prevent graft-versus-host disease are of great interest as well as the potential role of gut microbiota modulation. We reviewed the role of gut microbiota in the development of immune system and its involvement in the graft-versus-host disease, focusing on data available on humans.
KW - Gut microbiota has gained increasing interest in the pathogenesis
KW - Gut microbiota has gained increasing interest in the pathogenesis
UR - http://hdl.handle.net/10807/92925
U2 - 10.4084/mjhid.2016.025
DO - 10.4084/mjhid.2016.025
M3 - Article
SN - 2035-3006
VL - 8
SP - e2016025-e2016025
JO - Mediterranean Journal of Hematology and Infectious Diseases
JF - Mediterranean Journal of Hematology and Infectious Diseases
ER -