The gastrointestinal microbiome - functional interference between stomach and intestine

Risultato della ricerca: Contributo in rivistaArticolo in rivista

25 Citazioni (Scopus)


The gastrointestinal (GI) tract is a complex and dynamic network with interplay between various gut mucosal cells and their defence molecules, the immune system, food particles, and the resident microbiota. This ecosystem acts as a functional unit organized as a semipermeable multi-layer system that allows the absorption of nutrients and macromolecules required for human metabolic processes and, on the other hand, protects the individual from potentially invasive microorganisms. Commensal microbiota and the host are a unique entity in a continuum along the GI tract, every change in one of these players is able to modify the whole homeostasis. In the stomach, Helicobacter pylori is a gram-negative pathogen that is widespread all over the world, infecting more than 50% of the world's population. In this scenario, H. pylori infection is associated with changes in the gastric microenvironment, which in turn affects the gastric microbiota composition, but also might trigger large intestinal microbiota changes. It is able to influence all the vital pathways of human system and also to influence microbiota composition along the GI tract. This can cause a change in the normal functions exerted by intestinal commensal microorganisms leading to a new gastrointestinal physiological balance. This review focuses and speculates on the possible interactions between gastric microorganisms and intestinal microbiota and on the consequences of this interplay in modulating gut health.
Lingua originaleEnglish
pagine (da-a)995-1002
Numero di pagine8
Stato di pubblicazionePubblicato - 2014


  • Clostridia
  • Gastric intestinal interference
  • Gastric microbiota
  • Gastric modulation of Gut microbiota
  • Gut microbiota
  • Helicobacter pylori


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