The evolution of in vitro models of lung fibrosis: promising prospects for drug discovery

Emanuel Kolanko, Anna Cargnoni, Andrea Papait, Antonietta Rosa Silini, Piotr Czekaj, Ornella Parolini*

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Lung fibrosis is a complex process, with unknown underlying mechanisms, involving various triggers, diseases and stimuli. Different cell types (epithelial cells, endothelial cells, fibroblasts and macrophages) interact dynamically through multiple signalling pathways, including biochemical/molecular and mechanical signals, such as stiffness, affecting cell function and differentiation. Idiopathic pulmonary fibrosis (IPF) is the most common fibrosing interstitial lung disease (fILD), characterised by a notably high mortality. Unfortunately, effective treatments for advanced fILD, and especially IPF and non-IPF progressive fibrosing phenotype ILD, are still lacking. The development of pharmacological therapies faces challenges due to limited knowledge of fibrosis pathogenesis and the absence of pre -clinical models accurately representing the complex features of the disease. To address these challenges, new model systems have been developed to enhance the translatability of preclinical drug testing and bridge the gap to human clinical trials. The use of two- and three-dimensional in vitro cultures derived from healthy or diseased individuals allows for a better understanding of the underlying mechanisms responsible for lung fibrosis. Additionally, microfluidics systems, which replicate the respiratory system's physiology ex vivo, offer promising opportunities for the development of effective therapies, especially for IPF.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaEuropean Respiratory Review
Volume33
DOI
Stato di pubblicazionePubblicato - 2024

Keywords

  • Disease progression
  • Drug discovery
  • Endothelial cells/pathology
  • Humans
  • Idiopathic Pulmonary Fibrosis* / pathology
  • Lung Diseases, Interstitial*

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