TY - JOUR
T1 - The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation
AU - Ciurea, Stefan O.
AU - Cao, Kai
AU - Fernadez-Vina, Marcelo
AU - Kongtim, Piyanuch
AU - Malki, Monzr Al
AU - Fuchs, Ephraim
AU - Luznik, Leo
AU - Huang, Xiao-Jun
AU - Ciceri, Fabio
AU - Locatelli, Franco
AU - Aversa, Franco
AU - Castagna, Luca
AU - Bacigalupo, Andrea
AU - Martelli, Massimo
AU - Blaise, Didier
AU - Handgretinger, Rupert
AU - Roy, Denis-Claude
AU - O'Donnell, Paul
AU - Bashey, Asad
AU - Lazarus, Hillard M.
AU - Ballen, Karen
AU - Savani, Bipin N.
AU - Mohty, Mohamad
AU - Nagler, Arnon
PY - 2018
Y1 - 2018
N2 - Haploidentical donors are now increasingly considered for transplantation in the absence of HLA-matched donors or when an urgent transplant is needed. Donor-specific anti-HLA antibodies (DSA) have been recently recognized as an important barrier against successful engraftment of donor cells, which can affect transplant survival. DSA appear more prevalent in this type of transplant due to higher likelihood of alloimmunization of multiparous females against offspring's HLA antigens, and the degree of mismatch. Here we summarize the evidence for the role of DSA in the development of primary graft failure in haploidentical transplantation and provide consensus recommendations from the European Society for Blood and Marrow Transplant Group on testing, monitoring, and treatment of patients with DSA receiving haploidentical hematopoietic progenitor cell transplantation.
AB - Haploidentical donors are now increasingly considered for transplantation in the absence of HLA-matched donors or when an urgent transplant is needed. Donor-specific anti-HLA antibodies (DSA) have been recently recognized as an important barrier against successful engraftment of donor cells, which can affect transplant survival. DSA appear more prevalent in this type of transplant due to higher likelihood of alloimmunization of multiparous females against offspring's HLA antigens, and the degree of mismatch. Here we summarize the evidence for the role of DSA in the development of primary graft failure in haploidentical transplantation and provide consensus recommendations from the European Society for Blood and Marrow Transplant Group on testing, monitoring, and treatment of patients with DSA receiving haploidentical hematopoietic progenitor cell transplantation.
KW - HSCT
KW - HSCT
UR - http://hdl.handle.net/10807/229149
U2 - 10.1038/s41409-017-0062-8
DO - 10.1038/s41409-017-0062-8
M3 - Article
SN - 0268-3369
VL - 53
SP - 521
EP - 534
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
ER -