The epithelial–mesenchymal transition in cancer: a potential critical topic for translational proteomic research

Roberto Scatena, Maria Antonietta Isgro', Patrizia Bottoni

Risultato della ricerca: Contributo in rivistaArticolo in rivista

13 Citazioni (Scopus)

Abstract

The epithelial-mesenchymal transition (EMT) is a morphogenetic process that results in a loss of epithelial characteristics and the acquisition of a mesenchymal phenotype. First described in embryogenesis, the EMT has been recently implicated in carcinogenesis and tumor progression. In addition, recent evidence has shown that stem-like cancer cells present the hallmarks of the EMT. Some of the molecular mechanisms related to the interrelationships between cancer pathophysiology and the EMT are well-defined. Nevertheless, the precise molecular mechanism by which epithelial cancer cells acquire the mesenchymal phenotype remains largely unknown. This review focuses on various proteomic strategies with the goal of better understanding the physiological and pathological mechanisms of the EMT process
Lingua originaleEnglish
pagine (da-a)115-133
Numero di pagine19
RivistaExpert Review of Proteomics
Volume2016
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • cancer stem cells

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