The endocannabinoid-alcohol crosstalk: Recent advances on a bi-faceted target

Giuseppe Tringali, Gianluca Lavanco, Valentina Castelli, Anna Brancato, Fulvio Plescia, Carla Cannizzaro

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

4 Citazioni (Scopus)

Abstract

Increasing evidence has focusesed on the endocannabinoid system as a relevant player in the induction of aberrant synaptic plasticity and related addictive phenotype following chronic excessive alcohol drinking. In addition, the endocannabinoid system is implicated in the pathogenesis of alcoholic liver disease. Interestingly, whereas the involvement of CB1 receptors in alcohol rewarding properties is established, the central and peripheral action of CB2 signalling is still to be elucidated. This review aims at giving the input to deepen knowledge on the role of the endocannabinoid system, highlighting the advancing evidence that suggests that CB1 and CB2 receptors may play opposite roles in the regulation of both the reinforcing properties of alcohol in the brain and the mechanisms responsible for cell injury and inflammation in the hepatic tissue. The manipulation of the endocannabinoid system could represent a bi-faceted strategy to counteract alcohol-related dysfunction in central transmission and liver structural and functional disarrangement.
Lingua originaleEnglish
pagine (da-a)889-896
Numero di pagine8
RivistaCLINICAL AND EXPERIMENTAL PHARMACOLOGY & PHYSIOLOGY.
Volume45
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • 1
  • 2
  • CB
  • alcohol
  • brain
  • endocannabinoids
  • liver

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