The emerging role of the BDNF-TrkB signaling pathway in the modulation of pain perception

Elisabetta Tabolacci, Cinzia Dello Russo, Natalia Cappoli, Paola Aceto

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

2 Citazioni (Scopus)

Abstract

The brain derived neurotrophic factor (BDNF) is a crucial neuromodulator in pain transmission both in peripheral and central nervous system (CNS). Despite evidence of a pro-nociceptive role of BDNF, recent studies have reported contrasting results, including anti-nociceptive and anti-inflammatory activities. Moreover, BDNF polymorphisms can interfere with BDNF role in pain perception. In Val66Met carriers, the Met allele may have a dual role, with anti-nociceptive actions in normal condition and pro-nociceptive effects during chronic pain. In order to elucidate the main effects of BDNF in nociception, we reviewed the main characteristics of this neurotrophin, focusing on its involvement in pain.
Lingua originaleEnglish
pagine (da-a)1-11
Numero di pagine11
RivistaJournal of Neuroimmunology
Volume349
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • Brain derived neurotrophic factor
  • Inflammatory pain
  • Neuropathic pain
  • Molecular biomarkers
  • Microglia

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