The electronic nose in respiratory medicine.

Paolo Montuschi, Nadia Mores, Andrea Trové, Chiara Mondino, Peter J. Barnes

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

120 Citazioni (Scopus)


Several volatile organic compounds have been identified in exhaled breath in healthy subjects and patients with respiratory diseases by gas chromatography/mass spectrometry. Identification of selective patterns of volatile organic compounds in exhaled breath could be used as a biomarker of inflammatory lung diseases. An electronic nose (e-nose) is an artificial sensor system that generally consists of an array of chemical sensors for detection of volatile organic compound profiles (breathprints) and an algorithm for pattern recognition. E-noses are handheld, portable devices that provide immediate results. E-noses discriminate between patients with respiratory disease, including asthma, COPD and lung cancer, and healthy control subjects, and also among patients with different respiratory diseases. E-nose breathprints are associated with airway inflammation activity. In combination with other 'omics' platforms, e-nose technology might contribute to the identification of new surrogate markers of pulmonary inflammation and subphenotypes of patients with respiratory diseases, provide a molecular basis to a personalized pharmacological treatment, and facilitate the development of new drugs.
Lingua originaleEnglish
pagine (da-a)72-84
Numero di pagine13
Stato di pubblicazionePubblicato - 2013


  • COPD
  • asthma
  • chemical sensor array
  • cystic fibrosis
  • electronic nose
  • lung cancer
  • respiratory inflammation
  • respiratory medicine
  • therapeutic monitoring of airway inflammation


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