The effects of itopride on oesophageal motility and lower oesophageal sphincter function in man

Antonio Gasbarrini, Emidio Scarpellini, R Vos, K Blondeau, V Boecxstaens, R Farré, J. Tack

Risultato della ricerca: Contributo in rivistaArticolo in rivista

21 Citazioni (Scopus)

Abstract

BACKGROUND: Itopride is a new prokinetic agent that combines antidopaminergic and cholinesterase inhibitory actions. Previous studies suggested that itopride improves heartburn in functional dyspepsia, and decreases oesophageal acid exposure in gastro-oesophageal reflux disease. It remains unclear whether this effect is due to effects of itopride on the lower oesophageal sphincter (LES). AIMS: To study the effects of itopride on fasting and postprandial LES function in healthy subjects. METHODS: Twelve healthy volunteers (five men; 32.6 ± 2.0 years) underwent three oesophageal sleeve manometry studies after 3 days premedication with itopride 50 mg, itopride 100 mg or placebo t.d.s. Drug was administered after 30 min and a standardized meal was administered after 90 min, with measurements continuing to 120 min postprandially. Throughout the study, 10 wet swallows were administered at 30-min intervals, and gastrointestinal symptoms were scored on 100 mm visual analogue scales at 15-min intervals. RESULTS: Lower oesophageal sphincter resting pressures, swallow-induced relaxations and the amplitude or duration of peristaltic contractions were not altered by both doses of itopride, at all time points. Itopride pre-treatment inhibited the meal-induced rise of transient LES relaxations (TLESRs). CONCLUSIONS: Itopride inhibits TLESRs without significantly affecting oesophageal peristaltic function or LES pressure. These observations support further studies with itopride in gastro-oesophageal reflux disease.
Lingua originaleEnglish
pagine (da-a)99-105
Numero di pagine7
RivistaALIMENTARY PHARMACOLOGY AND THERAPEUTICS
Volume33
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Adult
  • Benzamides
  • Benzyl Compounds
  • Cross-Over Studies
  • Double-Blind Method
  • Esophageal Sphincter, Lower
  • Fasting
  • Female
  • Gastric Emptying
  • Gastroesophageal Reflux
  • Humans
  • Male
  • Treatment Outcome
  • Young Adult

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