The effects of iridium on the renal function of female Wistar rats

Ivo Iavicoli, Luca Fontana, Antonio Bergamaschi, A Marinaccio, A Alimonti, A Pino, Ej Calabrese

Risultato della ricerca: Contributo in rivistaArticolo in rivista

10 Citazioni (Scopus)

Abstract

Despite the widespread use of iridium (Ir) in catalytic converters for improved capacity for reducing carbon monoxide (CO), hydrocarbon (HC) and nitrogen oxide (NO(x)) emissions, there is a lack of studies that have assessed possible toxicological hazards of exposure to Ir. The present investigation indicates that female Wistar rats exposed to Ir in the drinking water for 90 days displayed renal toxicity based on the elevated urinary retinol binding protein (RBP) and albumin. The RBP was more sensitive to albumin, showing significant increases at 0.01 mg/L.
Lingua originaleEnglish
pagine (da-a)1795-1799
Numero di pagine5
RivistaEcotoxicology and Environmental Safety
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Albuminuria
  • Animals
  • Drinking Water
  • Environmental Pollutants
  • Female
  • Iridium
  • Kidney
  • Kidney Diseases
  • Rats
  • Rats, Wistar
  • Retinol-Binding Proteins
  • Toxicity Tests, Subchronic
  • beta 2-Microglobulin

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