TY - JOUR
T1 - The Effects of Granulocyte Colony-Stimulating Factor in Patients with a Large Anterior Wall Acute Myocardial Infarction to Prevent Left Ventricular Remodeling: A 10-Year Follow-Up of the RIGENERA Study
AU - Leone, Antonio Maria
AU - D'Amario, Domenico
AU - Cannata, Francesco
AU - Graziani, Francesca
AU - Borovac, Josip A.
AU - Leone, Giuseppe
AU - De Stefano, Valerio
AU - Basile, Eloisa
AU - Siracusano, Andrea
AU - Galiuto, Leonarda
AU - Locorotondo, Gabriella
AU - Porto, Italo
AU - Vergallo, Rocco
AU - Canonico, Francesco
AU - Restivo, Attilio
AU - Rebuzzi, Antonio Giuseppe
AU - Crea, Filippo
PY - 2020
Y1 - 2020
N2 - Background: the RIGENERA trial assessed the efficacy of granulocyte-colony stimulating factor (G-CSF) in the improvement of clinical outcomes in patients with severe acute myocardial infarction. However, there is no evidence available regarding the long-term safety and efficacy of this treatment.
Methods: in order to evaluate the long-term effects on the incidence of major adverse events, on the symptom burden, on the quality of life and the mean life expectancy and on the left ventricular (LV) function, we performed a clinical and echocardiographic evaluation together with an assessment using the Minnesota Living with Heart Failure Questionnaire (MLHFQ) and the Seattle Heart Failure Model (SHFM) at 10-years follow-up, in the patients cohorts enrolled in the RIGENERA trial.
Results: thirty-two patients were eligible for the prospective clinical and echocardiography analyses. A significant reduction in adverse LV remodeling was observed in G-CSF group compared to controls, 9% vs. 48% (p = 0.030). The New York Heart Association (NYHA) functional class was lower in G-CSF group vs. controls (p = 0.040), with lower burden of symptoms and higher quality of life (p = 0.049). The mean life expectancy was significantly higher in G-CSF group compared to controls (15 ± 4 years vs. 12 ± 4 years, p = 0.046. No difference was found in the incidence of major adverse events.
Conclusions: this longest available follow-up on G-CSF treatment in patients with severe acute myocardial infarction (AMI) showed that this treatment was safe and associated with a reduction of adverse LV remodeling and higher quality of life, in comparison with standard-of-care treatment.
AB - Background: the RIGENERA trial assessed the efficacy of granulocyte-colony stimulating factor (G-CSF) in the improvement of clinical outcomes in patients with severe acute myocardial infarction. However, there is no evidence available regarding the long-term safety and efficacy of this treatment.
Methods: in order to evaluate the long-term effects on the incidence of major adverse events, on the symptom burden, on the quality of life and the mean life expectancy and on the left ventricular (LV) function, we performed a clinical and echocardiographic evaluation together with an assessment using the Minnesota Living with Heart Failure Questionnaire (MLHFQ) and the Seattle Heart Failure Model (SHFM) at 10-years follow-up, in the patients cohorts enrolled in the RIGENERA trial.
Results: thirty-two patients were eligible for the prospective clinical and echocardiography analyses. A significant reduction in adverse LV remodeling was observed in G-CSF group compared to controls, 9% vs. 48% (p = 0.030). The New York Heart Association (NYHA) functional class was lower in G-CSF group vs. controls (p = 0.040), with lower burden of symptoms and higher quality of life (p = 0.049). The mean life expectancy was significantly higher in G-CSF group compared to controls (15 ± 4 years vs. 12 ± 4 years, p = 0.046. No difference was found in the incidence of major adverse events.
Conclusions: this longest available follow-up on G-CSF treatment in patients with severe acute myocardial infarction (AMI) showed that this treatment was safe and associated with a reduction of adverse LV remodeling and higher quality of life, in comparison with standard-of-care treatment.
KW - G-CSF
KW - granulocyte colony-stimulating factor
KW - left ventricular remodeling
KW - long-term effects
KW - myocardial infarction
KW - quality of life
KW - G-CSF
KW - granulocyte colony-stimulating factor
KW - left ventricular remodeling
KW - long-term effects
KW - myocardial infarction
KW - quality of life
UR - http://hdl.handle.net/10807/166827
U2 - 10.3390/jcm9041214
DO - 10.3390/jcm9041214
M3 - Article
SN - 2077-0383
VL - 9
SP - 1214-N/A
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
ER -