The effects of 5-HT3 receptor antagonists on cisplatin-induced emesis in the pigeon

Paolo Preziosi, Maria Martire, Giacomo Pozzoli, Pierluigi Navarra, M D'Amato, R Del Carmine

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

21 Citazioni (Scopus)

Abstract

In the present study, the emetic effect of the anticancer drug cisplatin, and the protective effects of 5-HT3 receptor antagonists against cisplatin emesis were investigated in the pigeon. The experimental set-up involved the i.v. administration of drugs and subsequent observation of the percentage of vomiting animals and the number of emetic episodes per vomiting animal. It was observed that cisplatin induced dose-dependent emesis in the pigeon. 5-HT3 receptor antagonists afforded partial protection against cisplatin emesis, although some of them, i.e. indole, indole-like derivatives and zacopride, displayed intrinsic emetic activity. A serotonergic mechanism appears to be involved in both cisplatin- and 5-HT3 receptor antagonist-induced emesis, since pretreatment with an inhibitor of 5-HT synthesis, para-chlorophenylalanine (pCPA), prevented vomiting induced by either cisplatin or 5-HT3 receptor antagonists. It is concluded that the intrinsic emetic effects of 5-HT3 receptor antagonists provide pharmacological evidence of species differences in the properties of 5-HT3 receptors.
Lingua originaleEnglish
pagine (da-a)343-350
Numero di pagine8
RivistaEuropean Journal of Pharmacology
Volume221
Stato di pubblicazionePubblicato - 1992

Keywords

  • Animals
  • Cisplatin
  • Columbidae
  • Dose-Response Relationship, Drug
  • Female
  • Male
  • Receptors, Serotonin
  • Serotonin Antagonists
  • Species Specificity
  • Vomiting

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