TY - JOUR
T1 - The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing-remitting multiple sclerosis.
AU - Frisullo, Giovanni
AU - Mirabella, Massimiliano
AU - Angelucci, Francesco
AU - Caggiula, Marcella
AU - Morosetti, Roberta
AU - Sancricca, Cristina
AU - Patanella, Agata Katia
AU - Nociti, Viviana
AU - Iorio, Raffaele
AU - Bianco, Assunta
AU - Tomassini, Valentina
AU - Pozzilli, Carlo
AU - Tonali, Pietro Attilio
AU - Matarese, Giuseppe
AU - Batocchi, Anna Paola
PY - 2007
Y1 - 2007
N2 - In this study we observed higher serum leptin levels in relapsing-remitting multiple sclerosis (RRMS) patients during remission than in controls. The expression of leptin receptor (ObR) was higher in CD8+ T cells and monocytes from RRMS patients in relapse than in patients in remission and in controls. Relapsing patients showed high levels of pSTAT3 and low expression of SOCS3 and leptin administration induced an up-regulation of pSTAT3 only in monocytes from patients in relapse. Our data suggest that ObR may be involved in the development of clinical relapses in RRMS patients and suggest a rationale for potential targeting of the leptin axis during MS.
AB - In this study we observed higher serum leptin levels in relapsing-remitting multiple sclerosis (RRMS) patients during remission than in controls. The expression of leptin receptor (ObR) was higher in CD8+ T cells and monocytes from RRMS patients in relapse than in patients in remission and in controls. Relapsing patients showed high levels of pSTAT3 and low expression of SOCS3 and leptin administration induced an up-regulation of pSTAT3 only in monocytes from patients in relapse. Our data suggest that ObR may be involved in the development of clinical relapses in RRMS patients and suggest a rationale for potential targeting of the leptin axis during MS.
KW - leptin
KW - multiple sclerosis
KW - leptin
KW - multiple sclerosis
UR - http://hdl.handle.net/10807/7698
M3 - Article
SN - 0165-5728
VL - 2007
SP - 174
EP - 183
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
ER -