The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing-remitting multiple sclerosis.

Giovanni Frisullo; Massimiliano Mirabella; Francesco Angelucci; Marcella Caggiula; Roberta Morosetti; Cristina Sancricca; Agata Katia Patanella; Viviana Nociti; Raffaele Iorio; Assunta Bianco; Valentina Tomassini; Carlo Pozzilli; Pietro Attilio Tonali; Giuseppe Matarese; Anna Paola Batocchi

The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing-remitting multiple sclerosis.

Giovanni Frisullo, Massimiliano Mirabella, Francesco Angelucci, Marcella Caggiula, Roberta Morosetti, Cristina Sancricca, Agata Katia Patanella, Viviana Nociti, Raffaele Iorio, Assunta Bianco, Valentina Tomassini, Carlo Pozzilli, Pietro Attilio Tonali, Giuseppe Matarese, Anna Paola Batocchi

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

59 Citazioni (Scopus)

Abstract

In this study we observed higher serum leptin levels in relapsing-remitting multiple sclerosis (RRMS) patients during remission than in controls. The expression of leptin receptor (ObR) was higher in CD8+ T cells and monocytes from RRMS patients in relapse than in patients in remission and in controls. Relapsing patients showed high levels of pSTAT3 and low expression of SOCS3 and leptin administration induced an up-regulation of pSTAT3 only in monocytes from patients in relapse. Our data suggest that ObR may be involved in the development of clinical relapses in RRMS patients and suggest a rationale for potential targeting of the leptin axis during MS.

Lingua originale	English
pagine (da-a)	174-183
Numero di pagine	10
Rivista	Journal of Neuroimmunology
Volume	2007
Stato di pubblicazione	Pubblicato - 2007

Keywords

leptin
multiple sclerosis

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Frisullo, G., Mirabella, M., Angelucci, F., Caggiula, M., Morosetti, R., Sancricca, C., Patanella, A. K., Nociti, V., Iorio, R., Bianco, A., Tomassini, V., Pozzilli, C., Tonali, P. A., Matarese, G., & Batocchi, A. P. (2007). The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing-remitting multiple sclerosis. Journal of Neuroimmunology, 2007, 174-183.

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title = "The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing-remitting multiple sclerosis.",

abstract = "In this study we observed higher serum leptin levels in relapsing-remitting multiple sclerosis (RRMS) patients during remission than in controls. The expression of leptin receptor (ObR) was higher in CD8+ T cells and monocytes from RRMS patients in relapse than in patients in remission and in controls. Relapsing patients showed high levels of pSTAT3 and low expression of SOCS3 and leptin administration induced an up-regulation of pSTAT3 only in monocytes from patients in relapse. Our data suggest that ObR may be involved in the development of clinical relapses in RRMS patients and suggest a rationale for potential targeting of the leptin axis during MS.",

keywords = "leptin, multiple sclerosis, leptin, multiple sclerosis",

author = "Giovanni Frisullo and Massimiliano Mirabella and Francesco Angelucci and Marcella Caggiula and Roberta Morosetti and Cristina Sancricca and Patanella, {Agata Katia} and Viviana Nociti and Raffaele Iorio and Assunta Bianco and Valentina Tomassini and Carlo Pozzilli and Tonali, {Pietro Attilio} and Giuseppe Matarese and Batocchi, {Anna Paola}",

year = "2007",

language = "English",

volume = "2007",

pages = "174--183",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier B.V.",

}

Frisullo, G, Mirabella, M, Angelucci, F, Caggiula, M, Morosetti, R, Sancricca, C, Patanella, AK, Nociti, V, Iorio, R, Bianco, A, Tomassini, V, Pozzilli, C, Tonali, PA, Matarese, G & Batocchi, AP 2007, 'The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing-remitting multiple sclerosis.', Journal of Neuroimmunology, vol. 2007, pagg. 174-183.

The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing-remitting multiple sclerosis. / Frisullo, Giovanni; Mirabella, Massimiliano; Angelucci, Francesco et al.
In: Journal of Neuroimmunology, Vol. 2007, 2007, pag. 174-183.

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

TY - JOUR

T1 - The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing-remitting multiple sclerosis.

AU - Frisullo, Giovanni

AU - Mirabella, Massimiliano

AU - Angelucci, Francesco

AU - Caggiula, Marcella

AU - Morosetti, Roberta

AU - Sancricca, Cristina

AU - Patanella, Agata Katia

AU - Nociti, Viviana

AU - Iorio, Raffaele

AU - Bianco, Assunta

AU - Tomassini, Valentina

AU - Pozzilli, Carlo

AU - Tonali, Pietro Attilio

AU - Matarese, Giuseppe

AU - Batocchi, Anna Paola

PY - 2007

Y1 - 2007

N2 - In this study we observed higher serum leptin levels in relapsing-remitting multiple sclerosis (RRMS) patients during remission than in controls. The expression of leptin receptor (ObR) was higher in CD8+ T cells and monocytes from RRMS patients in relapse than in patients in remission and in controls. Relapsing patients showed high levels of pSTAT3 and low expression of SOCS3 and leptin administration induced an up-regulation of pSTAT3 only in monocytes from patients in relapse. Our data suggest that ObR may be involved in the development of clinical relapses in RRMS patients and suggest a rationale for potential targeting of the leptin axis during MS.

AB - In this study we observed higher serum leptin levels in relapsing-remitting multiple sclerosis (RRMS) patients during remission than in controls. The expression of leptin receptor (ObR) was higher in CD8+ T cells and monocytes from RRMS patients in relapse than in patients in remission and in controls. Relapsing patients showed high levels of pSTAT3 and low expression of SOCS3 and leptin administration induced an up-regulation of pSTAT3 only in monocytes from patients in relapse. Our data suggest that ObR may be involved in the development of clinical relapses in RRMS patients and suggest a rationale for potential targeting of the leptin axis during MS.

KW - leptin

KW - multiple sclerosis

KW - leptin

KW - multiple sclerosis

UR - http://hdl.handle.net/10807/7698

M3 - Article

SN - 0165-5728

VL - 2007

SP - 174

EP - 183

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing-remitting multiple sclerosis.

Abstract

Keywords

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