The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing-remitting multiple sclerosis.

Massimiliano Mirabella, Giovanni Frisullo, Marcella Caggiula, Roberta Morosetti, Cristina Sancricca, Agata Katia Patanella, Viviana Nociti, Raffaele Iorio, Assunta Bianco, Pietro Attilio Tonali, Anna Paola Batocchi, Francesco Angelucci, Valentina Tomassini, Carlo Pozzilli, Giuseppe Matarese

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60 Citazioni (Scopus)

Abstract

In this study we observed higher serum leptin levels in relapsing-remitting multiple sclerosis (RRMS) patients during remission than in controls. The expression of leptin receptor (ObR) was higher in CD8+ T cells and monocytes from RRMS patients in relapse than in patients in remission and in controls. Relapsing patients showed high levels of pSTAT3 and low expression of SOCS3 and leptin administration induced an up-regulation of pSTAT3 only in monocytes from patients in relapse. Our data suggest that ObR may be involved in the development of clinical relapses in RRMS patients and suggest a rationale for potential targeting of the leptin axis during MS.
Lingua originaleEnglish
pagine (da-a)174-183
Numero di pagine10
RivistaJournal of Neuroimmunology
Volume2007
Stato di pubblicazionePubblicato - 2007

Keywords

  • leptin
  • multiple sclerosis

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