The ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K121Q polymorphism modulates the beneficial effect of weight loss on fasting glucose in non-diabetic individuals

Stefano Angelo Santini, M. Maranghi, S. Prudente, L. D'Erasmo, E. Morini, E. Ciociola, P. Coletta, A. Verrienti, S. Arciello, M. Copetti, F. Pellegrini, S. Morano, S. Filetti, V. Trischitta

Risultato della ricerca: Contributo in rivistaArticolo in rivista

5 Citazioni (Scopus)

Abstract

Several studies have reported that the ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K121Q polymorphism (rs1044498) interacts with increased adiposity in affecting glucose homeostasis and insulin sensitivity. Conversely, one would expect that the amelioration of glucose homeostasis observed after weight loss is modulated by the ENPP1 K121Q polymorphism. The aim of our study was to test such hypothesis, in non-diabetic overweight-obese individuals.
Lingua originaleEnglish
pagine (da-a)505-510
Numero di pagine6
RivistaNMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
Volume23
Stato di pubblicazionePubblicato - 2013

Keywords

  • Adiposity
  • Adult
  • Blood Glucose
  • Body Mass Index
  • Cholesterol, HDL
  • Diabetes Mellitus
  • Diet
  • Exercise
  • Fasting
  • Female
  • Genotype
  • Homeostasis
  • Humans
  • Insulin Resistance
  • Intervention Studies
  • Life Style
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Obesity
  • Overweight
  • Phosphoric Diester Hydrolases
  • Polymorphism, Genetic
  • Pyrophosphatases
  • Triglycerides
  • Weight Loss

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