The ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K121Q polymorphism modulates the beneficial effect of weight loss on fasting glucose in non-diabetic individuals

M. Maranghi; S. Prudente; L. D'Erasmo; E. Morini; E. Ciociola; P. Coletta; A. Verrienti; S. Arciello; M. Copetti; F. Pellegrini; Stefano Angelo Santini; S. Morano; S. Filetti; V. Trischitta

doi:10.1016/j.numecd.2011.11.003

The ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K121Q polymorphism modulates the beneficial effect of weight loss on fasting glucose in non-diabetic individuals

M. Maranghi, S. Prudente, L. D'Erasmo, E. Morini, E. Ciociola, P. Coletta, A. Verrienti, S. Arciello, M. Copetti, F. Pellegrini, Stefano Angelo Santini, S. Morano, S. Filetti, V. Trischitta

Risultato della ricerca: Contributo in rivista › Articolo in rivista

5 Citazioni (Scopus)

Abstract

Several studies have reported that the ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K121Q polymorphism (rs1044498) interacts with increased adiposity in affecting glucose homeostasis and insulin sensitivity. Conversely, one would expect that the amelioration of glucose homeostasis observed after weight loss is modulated by the ENPP1 K121Q polymorphism. The aim of our study was to test such hypothesis, in non-diabetic overweight-obese individuals.

Lingua originale	English
pagine (da-a)	505-510
Numero di pagine	6
Rivista	NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
Volume	23
DOI	https://doi.org/10.1016/j.numecd.2011.11.003
Stato di pubblicazione	Pubblicato - 2013

Keywords

Adiposity
Adult
Blood Glucose
Body Mass Index
Cholesterol, HDL
Diabetes Mellitus
Diet
Exercise
Fasting
Female
Genotype
Homeostasis
Humans
Insulin Resistance
Intervention Studies
Life Style
Male
Middle Aged
Multivariate Analysis
Obesity
Overweight
Phosphoric Diester Hydrolases
Polymorphism, Genetic
Pyrophosphatases
Triglycerides
Weight Loss

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10.1016/j.numecd.2011.11.003

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Maranghi, M., Prudente, S., D'Erasmo, L., Morini, E., Ciociola, E., Coletta, P., Verrienti, A., Arciello, S., Copetti, M., Pellegrini, F., Santini, S. A., Morano, S., Filetti, S., & Trischitta, V. (2013). The ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K121Q polymorphism modulates the beneficial effect of weight loss on fasting glucose in non-diabetic individuals. NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 23, 505-510. https://doi.org/10.1016/j.numecd.2011.11.003

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title = "The ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K121Q polymorphism modulates the beneficial effect of weight loss on fasting glucose in non-diabetic individuals",

abstract = "Several studies have reported that the ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K121Q polymorphism (rs1044498) interacts with increased adiposity in affecting glucose homeostasis and insulin sensitivity. Conversely, one would expect that the amelioration of glucose homeostasis observed after weight loss is modulated by the ENPP1 K121Q polymorphism. The aim of our study was to test such hypothesis, in non-diabetic overweight-obese individuals.",

keywords = "Adiposity, Adult, Blood Glucose, Body Mass Index, Cholesterol, HDL, Diabetes Mellitus, Diet, Exercise, Fasting, Female, Genotype, Homeostasis, Humans, Insulin Resistance, Intervention Studies, Life Style, Male, Middle Aged, Multivariate Analysis, Obesity, Overweight, Phosphoric Diester Hydrolases, Polymorphism, Genetic, Pyrophosphatases, Triglycerides, Weight Loss, Adiposity, Adult, Blood Glucose, Body Mass Index, Cholesterol, HDL, Diabetes Mellitus, Diet, Exercise, Fasting, Female, Genotype, Homeostasis, Humans, Insulin Resistance, Intervention Studies, Life Style, Male, Middle Aged, Multivariate Analysis, Obesity, Overweight, Phosphoric Diester Hydrolases, Polymorphism, Genetic, Pyrophosphatases, Triglycerides, Weight Loss",

author = "M. Maranghi and S. Prudente and L. D'Erasmo and E. Morini and E. Ciociola and P. Coletta and A. Verrienti and S. Arciello and M. Copetti and F. Pellegrini and Santini, {Stefano Angelo} and S. Morano and S. Filetti and V. Trischitta",

year = "2013",

doi = "10.1016/j.numecd.2011.11.003",

language = "English",

volume = "23",

pages = "505--510",

journal = "NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES",

issn = "0939-4753",

publisher = "-Amsterdam : Elsevier -Berlin : Springer -Milano: Medikal Press.",

}

Maranghi, M, Prudente, S, D'Erasmo, L, Morini, E, Ciociola, E, Coletta, P, Verrienti, A, Arciello, S, Copetti, M, Pellegrini, F, Santini, SA, Morano, S, Filetti, S & Trischitta, V 2013, 'The ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K121Q polymorphism modulates the beneficial effect of weight loss on fasting glucose in non-diabetic individuals', NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, vol. 23, pagg. 505-510. https://doi.org/10.1016/j.numecd.2011.11.003

The ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K121Q polymorphism modulates the beneficial effect of weight loss on fasting glucose in non-diabetic individuals. / Maranghi, M.; Prudente, S.; D'Erasmo, L. et al.
In: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, Vol. 23, 2013, pag. 505-510.

Risultato della ricerca: Contributo in rivista › Articolo in rivista

TY - JOUR

T1 - The ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K121Q polymorphism modulates the beneficial effect of weight loss on fasting glucose in non-diabetic individuals

AU - Maranghi, M.

AU - Prudente, S.

AU - D'Erasmo, L.

AU - Morini, E.

AU - Ciociola, E.

AU - Coletta, P.

AU - Verrienti, A.

AU - Arciello, S.

AU - Copetti, M.

AU - Pellegrini, F.

AU - Santini, Stefano Angelo

AU - Morano, S.

AU - Filetti, S.

AU - Trischitta, V.

PY - 2013

Y1 - 2013

N2 - Several studies have reported that the ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K121Q polymorphism (rs1044498) interacts with increased adiposity in affecting glucose homeostasis and insulin sensitivity. Conversely, one would expect that the amelioration of glucose homeostasis observed after weight loss is modulated by the ENPP1 K121Q polymorphism. The aim of our study was to test such hypothesis, in non-diabetic overweight-obese individuals.

AB - Several studies have reported that the ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K121Q polymorphism (rs1044498) interacts with increased adiposity in affecting glucose homeostasis and insulin sensitivity. Conversely, one would expect that the amelioration of glucose homeostasis observed after weight loss is modulated by the ENPP1 K121Q polymorphism. The aim of our study was to test such hypothesis, in non-diabetic overweight-obese individuals.

KW - Adiposity

KW - Adult

KW - Blood Glucose

KW - Body Mass Index

KW - Cholesterol, HDL

KW - Diabetes Mellitus

KW - Diet

KW - Exercise

KW - Fasting

KW - Female

KW - Genotype

KW - Homeostasis

KW - Humans

KW - Insulin Resistance

KW - Intervention Studies

KW - Life Style

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Obesity

KW - Overweight

KW - Phosphoric Diester Hydrolases

KW - Polymorphism, Genetic

KW - Pyrophosphatases

KW - Triglycerides

KW - Weight Loss

KW - Adiposity

KW - Adult

KW - Blood Glucose

KW - Body Mass Index

KW - Cholesterol, HDL

KW - Diabetes Mellitus

KW - Diet

KW - Exercise

KW - Fasting

KW - Female

KW - Genotype

KW - Homeostasis

KW - Humans

KW - Insulin Resistance

KW - Intervention Studies

KW - Life Style

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Obesity

KW - Overweight

KW - Phosphoric Diester Hydrolases

KW - Polymorphism, Genetic

KW - Pyrophosphatases

KW - Triglycerides

KW - Weight Loss

UR - http://hdl.handle.net/10807/63744

U2 - 10.1016/j.numecd.2011.11.003

DO - 10.1016/j.numecd.2011.11.003

M3 - Article

SN - 0939-4753

VL - 23

SP - 505

EP - 510

JO - NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

JF - NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

ER -

The ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K121Q polymorphism modulates the beneficial effect of weight loss on fasting glucose in non-diabetic individuals

Abstract

Keywords

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