The different expression of TRPM7 and MagT1 impacts on the proliferation of colon carcinoma cells sensitive or resistant to doxorubicin

Federica Wolf, Valentina Trapani, Alessandra Cazzaniga, Claudia Moscheni, Giovanna Farruggia, Azzurra Sargenti, Stefano Iotti, Jeanette A. M. Maier, Sara Castiglioni

Risultato della ricerca: Contributo in rivistaArticolo in rivista

11 Citazioni (Scopus)

Abstract

The processes leading to anticancer drug resistance are not completely unraveled. To get insights into the underlying mechanisms, we compared colon carcinoma cells sensitive to doxorubicin with their resistant counterpart. We found that resistant cells are growth retarded, and show staminal and ultrastructural features profoundly different from sensitive cells. The resistant phenotype is accompanied by the upregulation of the magnesium transporter MagT1 and the downregulation of the ion channel kinase TRPM7. We demonstrate that the different amounts of TRPM7 and MagT1 account for the different proliferation rate of sensitive and resistant colon carcinoma cells. It remains to be verified whether they are also involved in the control of other "staminal" traits.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaScientific Reports
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • magnesium transport, drug resistance

Fingerprint

Entra nei temi di ricerca di 'The different expression of TRPM7 and MagT1 impacts on the proliferation of colon carcinoma cells sensitive or resistant to doxorubicin'. Insieme formano una fingerprint unica.

Cita questo