The diagnostic role of pathergy test in patients with Behçet's disease from the Western Europe

Vitale Antonio, Virginia Berlengiero, Valeria Caggiano, Sara Barneschi, Mariam Mourabi, Jurgen Sota, Stefano Gentileschi, Maria Cristina Maggio, Carla Gaggiano, Maria Tarsia, Gian Marco Tosi, Giuseppe Lopalco, Claudia Fabiani, Bruno Frediani, Luca Cantarini

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

The aim of the study is to evaluate the frequency and features of positive pathergy test (PPT) in Italy, its role in the diagnosis of Behçet’s disease (BD), and any association with other BD-related manifestations. 52 BD patients, 52 patients with axial spondyloarthritis (ax-SpA), and 26 healthy controls (HCs) underwent intradermal injection of normal saline and intradermal needle soaked with fresh self-saliva. The results of pathergy tests were statistically analysed in the light of demographic, clinical, and therapeutic features of subjects enrolled. Pathergy test performed with saline resulted always negative in all groups. Skin prick test using self-saliva resulted in the occurrence of a papule in 3 (5.8%) BD patients and in 1 (1.9%) patient with ax-SpA. A ≥ 15 mm erythematous area surrounding the needle prick site was observed in 22 (42.3%) BD patients, 5 (9.6%) patients with ax-SpA, and 2 (7.7%) HCs (p = 0.00002). The frequency of skin erythema was significantly more frequent in patients with BD than those with ax-SpA (p < 0.0001) and HCs (p = 0.003). No statistically significant differences were observed between ax-SpA patients and HCs (p = 1.000). The occurrence of skin erythema at pathergy test was not associated with any BD-related clinical manifestation. Erythema at self-saliva prick test presented a sensitivity of 42.31% (CI 28.73–56.80%) and a specificity of 91.03% (CI 82.38–96.32%). The development of a ≥ 15 mm erythematous area at self-saliva prick test could be sufficient to unveil the hyper-reactivity of the innate immune system in BD patients from Western Europe, where the development of skin erythema shows good sensitivity and specificity toward the diagnosis of BD.
Lingua originaleEnglish
pagine (da-a)77-83
Numero di pagine7
RivistaINTERNAL AND EMERGENCY MEDICINE
Volume18
DOI
Stato di pubblicazionePubblicato - 2023

Keywords

  • Autoinflammatory diseases
  • Diagnosis
  • Management
  • Diagnostic test
  • Geographical differences
  • Diagnostic accuracy

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