The detection of neural autoantibodies in patients with antiepileptic-drug-resistant epilepsy predicts response to immunotherapy

Giacomo Della Marca, Amelia Evoli, Raffaele Iorio, Gabriella Colicchio, Paolo Maria Rossini, Catello Vollono, G. Assenza, M. Tombini, A. Benvenga

Risultato della ricerca: Contributo in rivistaArticolo in rivista

23 Citazioni (Scopus)

Abstract

The detection of antibodies binding neural antigens in patients with epilepsy has led to the definition of 'autoimmune epilepsy'. Patients with neural antibodies not responding to antiepileptic drugs (AEDs) may benefit from immunotherapy. Aim of this study was to evaluate the frequency of autoantibodies specific to neural antigens in patients with epilepsy and their response to immunotherapy.
Lingua originaleEnglish
pagine (da-a)70-78
Numero di pagine9
RivistaEUROPEAN JOURNAL OF NEUROLOGY
Volume22
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • Adult
  • Animals
  • Anticonvulsants
  • Autoantibodies
  • Drug Resistance
  • Epilepsy
  • Female
  • Humans
  • Immunotherapy
  • Male
  • Mice
  • Middle Aged
  • Treatment Outcome
  • antiepileptic drug resistant epilepsy
  • autoimmune epilepsy
  • leucine-rich glioma inactivated 1
  • synaptic antigens

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