The detection of neural autoantibodies in patients with antiepileptic-drug-resistant epilepsy predicts response to immunotherapy

Raffaele Iorio; G Assenza; M Tombini; G Colicchio; Giacomo Della Marca; A Benvenga; V Damato; Paolo Maria Rossini; C Vollono; D Plantone; A Marti; Ap Batocchi; Amelia Evoli

doi:10.1111/ene.12529

The detection of neural autoantibodies in patients with antiepileptic-drug-resistant epilepsy predicts response to immunotherapy

Raffaele Iorio^*, G Assenza, M Tombini, G Colicchio, Giacomo Della Marca, A Benvenga, V Damato, Paolo Maria Rossini, C Vollono, D Plantone, A Marti, Ap Batocchi, Amelia Evoli

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo

23 Citazioni (Scopus)

Abstract

The detection of antibodies binding neural antigens in patients with epilepsy has led to the definition of 'autoimmune epilepsy'. Patients with neural antibodies not responding to antiepileptic drugs (AEDs) may benefit from immunotherapy. Aim of this study was to evaluate the frequency of autoantibodies specific to neural antigens in patients with epilepsy and their response to immunotherapy.

Lingua originale	Inglese
pagine (da-a)	70-78
Numero di pagine	9
Rivista	European Journal of Neurology
Volume	22
Numero di pubblicazione	1
DOI	https://doi.org/10.1111/ene.12529
Stato di pubblicazione	Pubblicato - 2014

All Science Journal Classification (ASJC) codes

Neurologia
Neurologia (clinica)

Keywords

antiepileptic drug resistant epilepsy
autoimmune epilepsy
leucine-rich glioma inactivated 1
synaptic antigens

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10.1111/ene.12529

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Iorio, R., Assenza, G., Tombini, M., Colicchio, G., Della Marca, G., Benvenga, A., Damato, V., Rossini, P. M., Vollono, C., Plantone, D., Marti, A., Batocchi, A., & Evoli, A. (2014). The detection of neural autoantibodies in patients with antiepileptic-drug-resistant epilepsy predicts response to immunotherapy. European Journal of Neurology, 22(1), 70-78. https://doi.org/10.1111/ene.12529

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abstract = "The detection of antibodies binding neural antigens in patients with epilepsy has led to the definition of 'autoimmune epilepsy'. Patients with neural antibodies not responding to antiepileptic drugs (AEDs) may benefit from immunotherapy. Aim of this study was to evaluate the frequency of autoantibodies specific to neural antigens in patients with epilepsy and their response to immunotherapy.",

keywords = "antiepileptic drug resistant epilepsy, autoimmune epilepsy, leucine-rich glioma inactivated 1, synaptic antigens, antiepileptic drug resistant epilepsy, autoimmune epilepsy, leucine-rich glioma inactivated 1, synaptic antigens",

author = "Raffaele Iorio and G Assenza and M Tombini and G Colicchio and {Della Marca}, Giacomo and A Benvenga and V Damato and Rossini, {Paolo Maria} and C Vollono and D Plantone and A Marti and Ap Batocchi and Amelia Evoli",

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Iorio, R, Assenza, G, Tombini, M, Colicchio, G, Della Marca, G, Benvenga, A, Damato, V, Rossini, PM, Vollono, C, Plantone, D, Marti, A, Batocchi, A & Evoli, A 2014, 'The detection of neural autoantibodies in patients with antiepileptic-drug-resistant epilepsy predicts response to immunotherapy', European Journal of Neurology, vol. 22, n. 1, pagg. 70-78. https://doi.org/10.1111/ene.12529

TY - JOUR

T1 - The detection of neural autoantibodies in patients with antiepileptic-drug-resistant epilepsy predicts response to immunotherapy

AU - Iorio, Raffaele

AU - Assenza, G

AU - Tombini, M

AU - Colicchio, G

AU - Della Marca, Giacomo

AU - Benvenga, A

AU - Damato, V

AU - Rossini, Paolo Maria

AU - Vollono, C

AU - Plantone, D

AU - Marti, A

AU - Batocchi, Ap

AU - Evoli, Amelia

PY - 2014

Y1 - 2014

N2 - The detection of antibodies binding neural antigens in patients with epilepsy has led to the definition of 'autoimmune epilepsy'. Patients with neural antibodies not responding to antiepileptic drugs (AEDs) may benefit from immunotherapy. Aim of this study was to evaluate the frequency of autoantibodies specific to neural antigens in patients with epilepsy and their response to immunotherapy.

AB - The detection of antibodies binding neural antigens in patients with epilepsy has led to the definition of 'autoimmune epilepsy'. Patients with neural antibodies not responding to antiepileptic drugs (AEDs) may benefit from immunotherapy. Aim of this study was to evaluate the frequency of autoantibodies specific to neural antigens in patients with epilepsy and their response to immunotherapy.

KW - antiepileptic drug resistant epilepsy

KW - autoimmune epilepsy

KW - leucine-rich glioma inactivated 1

KW - synaptic antigens

KW - antiepileptic drug resistant epilepsy

KW - autoimmune epilepsy

KW - leucine-rich glioma inactivated 1

KW - synaptic antigens

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U2 - 10.1111/ene.12529

DO - 10.1111/ene.12529

M3 - Article

SN - 1351-5101

VL - 22

SP - 70

EP - 78

JO - European Journal of Neurology

JF - European Journal of Neurology

IS - 1

ER -

The detection of neural autoantibodies in patients with antiepileptic-drug-resistant epilepsy predicts response to immunotherapy

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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