-The decrease in cytokine concentration during albumin dialysis correlates with the prognosis of patients with acute on chronic liver failure

Maria Assunta Zocco, Rita Gaspari, Angelo Santoliquido, Roberto Antonio Flore, Paolo Tondi, Giovanni Battista Gasbarrini, Antonio Gasbarrini, Cristiana Di Campli, Marcello Candelli, Rodolfo Proietti, Paolo Pola, Maria Luisa Novi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

41 Citazioni (Scopus)

Abstract

Abstract BACKGROUND AND AIM: The clearance of plasma cytokines by means of albumin dialysis (MARS) has been demonstrated in various studies involving patients affected by either acute liver failure (ALF) or acute on chronic liver failure. The aim of the study was to measure the plasma levels of TNF-alpha, IL-6, and IL-1beta in patients with ALF after each MARS treatment to evaluate the relationship between variations in cytokines levels and patient prognosis. MATERIALS AND METHODS: Ten patients with ALF undergoing several MARS treatments were enrolled (group 1). Blood samples were collected before and after each MARS treatment to measure TNF-alpha, IL-6, and IL-1beta, and other hematochemical parameters. We also enrolled 10 patients with ALF who underwent standard therapy (group 2) as well as a control group of 10 healthy subjects matched for sex and age (group 3). RESULTS: MARS reduced total bilirubin levels, biliary acids, BUN, ammonia, TNF-alpha, IL-6, and IL-1beta (P < .05). Moreover, the reduction in inflammatory cytokines levels and improved prognosis were related. CONCLUSIONS: We confirmed the therapeutic efficacy of MARS treatment for ALF, which appeared to be related to removal of toxins and inflammatory cytokines determine that which patients prognosis.
Lingua originaleEnglish
pagine (da-a)2551-2553
Numero di pagine3
RivistaTransplantation Proceedings
Stato di pubblicazionePubblicato - 2005

Keywords

  • The decrease in cytokine concentration

Fingerprint

Entra nei temi di ricerca di '-The decrease in cytokine concentration during albumin dialysis correlates with the prognosis of patients with acute on chronic liver failure'. Insieme formano una fingerprint unica.

Cita questo