The changing scenario of hepatocellular carcinoma in Italy: an update

Antonio Gasbarrini, Gian Ludovico Rapaccini, Maria Teresa Di Marco, Nicoletta De Matthaeis, Francesco Conti, Monica Capasso, Mariateresa Guarino, Francesca Garuti, Andrea Neri, Francesca Avanzato, Annagiulia Gramenzi, Davide Rampoldi, Paola Rucci, Fabio Farinati, Edoardo G. Giannini, Fabio Piscaglia, Maria Di Marco, Eugenio Caturelli, Marco Zoli, Rodolfo SaccoGiuseppe Cabibbo, Fabio Marra, Andrea Mega, Filomena Morisco, Gianluca Svegliati-Baroni, Francesco G. Foschi, Gabriele Missale, Alberto Masotto, Gerardo Nardone, Giovanni Raimondo, Francesco Azzaroli, Gianpaolo Vidili, Maurizia R. Brunetto, Franco Trevisani, Maurizio Biselli, Paolo Caraceni, Francesca Garuti, Annagiulia Gramenzi, Andrea Neri, Valentina Santi, Alessandro Granito, Luca Muratori, Vito Sansone, Francesco Tovoli, Elton Dajti, Giovanni Marasco, Federico Ravaioli, Alberta Cappelli, Rita Golfieri, Cristina Mosconi, Matteo Renzulli, Ester Marina Cela, Antonio Facciorusso, Valentina Cacciato, Edoardo Casagrande, Alessandro Moscatelli, Gaia Pellegatta, Gloria Allegrini, Valentina Lauria, Giorgia Ghittoni, Giorgio Pelecca, Fabrizio Chegai, Fabio Coratella, Mariano Ortenzi, Elisabetta Biasini, Andrea Olivani, Alessandro Inno, Fabiana Marchetti, Anita Busacca, G. Cabibbo, Calogero Cammà, Vincenzo Di Martino, Giacomo Emanuele Maria Rizzo, Maria Stella Franzè, Carlo Saitta, Assunta Sauchella, Vittoria Bevilacqua, Dante Berardinelli, Alberto Borghi, Andrea Casadei Gardini, Fabio Conti, Alessandro Cucchetti, Anna Chiara Dall’Aglio, Giorgio Ercolani, Claudia Campani, Chiara Di Bonaventura, Stefano Gitto, Pietro Coccoli Antonio Malerba, Mario Capasso, Maria Guarino, Filippo Oliveri, Veronica Romagnoli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Background and aims: Epidemiology of hepatocellular carcinoma (HCC) is changing in most areas of the world. This study aimed at updating the changing scenario of aetiology, clinical presentation, management and prognosis of HCC in Italy during the last 15 years. Methods: Retrospective analysis of the Italian Liver Cancer (ITA.LI.CA) database included 6034 HCC patients managed in 23 centres from 2004 to 2018. Patients were divided into three groups according to the date of cancer diagnosis (2004-2008, 2009-2013 and 2014-2018). Results: The main results were: (i) a progressive patient ageing; (ii) a progressive increase of non-viral cases and, particularly, of ‘metabolic’ and ‘metabolic + alcohol’ HCCs; (iii) a slightly decline of cases diagnosed under surveillance, but with an incremental use of the semiannual schedule; (iv) a favourable cancer stage migration; (v) an increased use of radiofrequency ablation to the detriment of percutaneous ethanol injection; (vi) improved outcomes of ablative and transarterial treatments; (vii) an improved overall survival (adjusted for the lead time in surveyed patients) in the last calendar period, particularly in viral patients; (viii) a large gap between the number of potential candidates (according to oncologic criteria and age) to liver transplant and that of transplanted patients. Conclusions: During the last 15 years several aspects of HCC scenario have changed, as well as its management. The improvement in patient survival observed in the last period was likely because of a larger use of thermal ablation with respect to the less effective alcohol injection and to an improved management of intermediate stage patients.
Lingua originaleEnglish
pagine (da-a)585-597
Numero di pagine13
RivistaLiver International
Volume41
DOI
Stato di pubblicazionePubblicato - 2021

Keywords

  • epidemiology
  • hepatocellular carcinoma
  • survival
  • treatment
  • Liver Neoplasms
  • Italy
  • Neoplasm Staging
  • Retrospective Studies
  • Carcinoma, Hepatocellular
  • Humans

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