The caveolar membrane system in endothelium: From cell signaling to vascular pathology

Alessio D'Alessio, Gigliola Sica, Antonio Filippini

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

9 Citazioni (Scopus)

Abstract

Caveolae are 50- to 100-nm cholesterol and glycosphingolipid-rich flask-shaped invaginations commonly observed in many terminally differentiated cells. These organelles have been described in many cell types and are particularly abundant in endothelial cells, where they have been involved in the regulation of certain signaling pathways. Specific scaffolding proteins termed caveolins, along with the more recently discovered members of the cavin family, represent the major protein components during caveolae biogenesis. In addition, multiple studies aimed to investigate the expression and the regulation of these proteins significantly contributed to elucidate the role of caveolae and caveolins in endothelial cell physiology and disease. The aim of this review is to survey recent evidence of the involvement of the caveolar network in endothelial cell biology and endothelial cell dysfunction.
Lingua originaleEnglish
pagine (da-a)5060-5071
Numero di pagine12
RivistaJournal of Cellular Biochemistry
Volume119
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • Biochemistry
  • Cell Biology
  • EPCs
  • Molecular Biology
  • angiogenesis
  • cancer
  • caveolae
  • caveolin
  • endothelial cells

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