The bladder epicheck test and cytology in the follow-up of patients with non-muscle-invasive high grade bladder carcinoma

Francesco Pierconti*, Maurizio Martini, Tonia Cenci, Vincenzo Fiorentino, Luca Di Gianfrancesco, Mauro Ragonese, Riccardo Bientinesi, Ernesto Rossi, Luigi Maria Larocca, Marco Racioppi, Pierfrancesco Bassi

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo in rivista


Background: The management of non-muscle invasive bladder carcinoma (NMIBC) after transurethral resection of a bladder tumor consists of adjuvant intravesical therapy and strict and long surveillance with urine cytology and cystoscopy. The Bladder EpiCheck test (Nucleix Ltd) (BE) is a newly developed urinary markers based on DNA methylation changes in a panel of 15 genomic biomarkers, with a promising performance in term of non-invasive NMIBC detection. Methods: In this study we prospectively enrolled 151 consecutive patients with high grade NMIBC, treated with intravesical BCG and mitomycin C therapy and evaluated during the follow-up by voided urine cytology and white-light cystoscopy, according to the European Association of Urology Guidelines. The Bladder EpiCheck test was performed at the same time of urine cytology in voided specimen. In all cases with positive cytology the diagnosis was confirmed by histology and a diagnosis was made according to the 2017 tumor, node, metastasis (TNM) classification and graded using both the 1973 and the 2004 World Health Organization (WHO) classifications. Results: At three months of follow-up, we reported similar overall specificity rates for BE and urine cytology (85,1% vs 86,3%). In the group of patients with carcinoma in situ (CIS), we found the same specificity for BE and urine cytology (81,4%), while in the groups of patients with papillary high grade NMIBC, the specificity of BE was higher compared to cytology (96,3% vs 90,4%). The sensitivity of BE was always higher compared to cytology during all the follow-up both for papillary NMIBC and CIS. Conclusion: In the early follow-up of NMIBC the EpiCheck test might replace urinary cytology.
Lingua originaleEnglish
pagine (da-a)108-108.e25
RivistaUrologic Oncology
Stato di pubblicazionePubblicato - 2022


  • Bladder Carcinoma
  • Cancer follow-up
  • Carcinoma in Situ
  • Cystoscopy
  • EpiCheck Test
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Paris System
  • Urinary Bladder
  • Urinary Bladder Neoplasms
  • Urinary Cytology


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